Senior Scientist Resume Examples and Templates

Senior Scientist

• Developed stable formulations with longer shelf life and reduced polyelectrolyte effects.
• Conducted large-scale polymer synthesis and functionalization for surface and DNA attachment.
• Optimized oligonucleotide conjugation chemistries for various formulations.
• Implemented in-process SDS-PAGE QC methods for efficient quality control.
• Collaborated with the development team to ensure a seamless transfer from early research to development.
• Improved polymeric materials for flow cell applications in DNA sequencing.
• Synthesized, optimized composition, and validated polymers, resulting in a significant reduction in signal loss during sequencing runs from 100% to 30%.
• Determined polymer structure-activity relationship for sequencing on Genapsys' proprietary CMOS semiconductor chip.

Senior Scientist

• Perform high-throughput peptide synthesis using automated microwave-assisted peptide synthesizers.
• Collaborate with interdisciplinary teams of scientists from different divisions.
• Manage inventory of lab common stocks and optimize lab workflows for efficient resource utilization.
• Maintain and troubleshoot critical lab instrumentation to ensure optimal performance.
• Provide scientific mentoring and deliver technical training to graduate students.

Protein Biology Senior scientist

• Development of antibodies against various targets, including primary, secondary, and tertiary antibodies.
• Cloning of recombinant antibody genes for production in mammalian cell lines.
• Fc engineering to optimize antibody function.
• Conjugation of antibodies for specific applications.
• Proficient in cell culture techniques for antibody production.
• Knowledge of antibody application methods and techniques.

Senior Scientist

• Development of integrated water-energy-emissions tools for Zephyr Corp.
• Researching climate and land use change impacts on hydrology and water resources systems at basin and urban scales in the Atlantica, Amazonia, and Indostan regions.
• Developing Montblanc glacier energy and water balances.
• Researching urban metabolism in emerging nations.
• Co-hosting the "Aqua Chronicles" podcast.
• Developing climate change curriculum.

Senior Scientist/Principal Scientist

• Establishment of a modality-independent project support foundation in discovery and development.
• Development of AWA PKDM LM and SM capabilities in collaboration with Larry Wienkers and Dan Rock, focusing on modality independence, cradle-to-grave project support, and scientific eminence.
• Serving as PKDM PTR for various LM and SM projects, including AMG 151, 208, 337, 319, and 357.
• Acting as the Inflammation in-licensing lead, representing PKDM.

Senior Scientist

• Development, validation, and transfer of analytical methods for drug substance and drug product.
• Serving as an analytical expert in cross-functional Pharmaceutical Development teams.
• Providing support for drug product registration, including both drug substance and drug product.
• Evaluation of due diligence projects.
• Project management for the implementation of an Electronic Laboratory Notebook (ELN).
• Introduction and implementation of key performance indicators.

QC Senior Scientist

• Collaborated as part of a cross-functional team involving Regulatory, Process Development, Manufacturing (MSAT), and QA.
• Coordinated and ensured timely completion of deliverables for each stage of work.
• Raised change controls, deviations, and CAPAs related to the product or process.
• Created, reviewed, and approved analytical specifications, Certificate of Analysis (CofA), QC release forms, and testing summaries.

Senior Scientist

• Led customer-centric product design throughout all stages of flow cytometry product development.
• Engaged with customers to identify and prioritize user needs, working cross-functionally to translate those needs into product features and requirements.
• Conducted design validation and usability testing to ensure products meet the needs of end-users.
• Identified use-related errors, risks, and implemented mitigations to enhance product safety and usability.

Senior Scientist

• Collaborated with industrial partners on the analysis of pharmaceutical biologics, covering all aspects from sample preparation to bioinformatics.
• Collaborated with industrial partners to develop integrated LC-MS-based pipelines for the characterization of biologics.
• Developed mass spectrometry methods for the analysis of biologics using Orbitraps, Q-Exactive, Fusion, QTOFs, and other instruments.

Senior Scientist

• Developed SFC-MS systems for mass spectrometry analyses and small-scale prep and purification.
• Developed general SFC methods applicable to a wide range of chemical families in drug discovery.
• Optimized column chemistry selection and mobile phase buffer selection for effective separations.
• Developed an SFC-to-mass spectrometry interface utilizing an APCI ionization platform.
• Developed software, timing, and methods for control and integration of all components.
• Integrated and automated hardware systems for mass-directed fractionation and high-throughput purification.
• Successfully purified a high volume of compounds per day with high purity using the 4-channel parallel SFC-MS system.
• Provided LC-MS and SFC-MS analyses to support various synthesis chemistries in medicinal, discovery, combinatorial, and process settings.

Senior Scientist, Mass Spectrometry

• Collaborating with industrial partners on the analysis of pharmaceutical biologics from sample preparation through bioinformatics.
• Collaborating with industrial partners on the development of integrated LC-MS-based pipelines for the characterization of biologics.
• Developing mass spectrometry methods for biologics using Orbitraps, Q-Exactive, Fusion, QTOFs, and other technologies.

Senior Scientist

• Conducted HRAM mass spectrometry and UPLC analyses for proteins, vaccines, antibody-drug conjugates (ADCs), and monoclonal antibodies (mAbs).
• Performed comprehensive LC-MS analyses on mAbs including peptide mapping, intact protein analysis, glycosylation profiling, amino acid sequencing, sequence coverage determination, identification of sequence variants, characterization of post-translational modifications, and disulfide bridge mapping.
• Developed targeted methods for the analysis of host cell proteins (HCPs) using HRAM mass spectrometry and implemented bioinformatic workflows and methods for data analysis.

Senior Scientist and Research Fellow

• Led proteomics and LC-MS/MS support, including methods development and informatics, to facilitate research initiatives at the institute.
• Developed Tandem Affinity Purification (TAP) methodologies for investigating protein-protein interactions.
• Spearheaded iTRAQ research and conducted proof-of-concept studies.
• Oversaw a team of three professionals, consisting of two Ph.D. scientists and one MS scientist.
• Managed a facility equipped with eight mass spectrometers to support research activities.

Senior Scientist

• Researched, designed, and implemented improved technologies and methods for high throughput purification and isolation of target compounds in combinatorial and exploratory libraries.
• Explored the feasibility and utility of Supercritical Fluid Chromatography (SFC) in various applications, including high-throughput purifications, small-scale prep, drug discovery, medicinal chemistry, combinatorial chemistry, and high throughput screening.
• Developed SFC-MS systems for mass spec analyses and small-scale prep and purification.
• Developed general SFC methods applicable to a wide range of chemical families encountered in drug discovery.
• Tested and optimized column chemistry selection for effective separations across broad compound classes.
• Tested and optimized mobile phase buffer selection and pH for effective separations across broad compound classes.
• Developed an effective SFC-to-Mass Spectrometry interface for seamless integration of SFC and mass spectrometry techniques.