Thomas Pisanic, Ii

• Well-qualified Scientist with 12 years of hands-on biomedical research experience, including 7 years in the development of commercial in vitro diagnostic and cell assays
• Solid experience base in numerous research areas such as: bacterial and mammalian cell culture, immunodiagnostics, nucleic acid diagnostics, cell-based diagnostics and novel bioconjugation chemistries
• Diverse range of abilities including project management, data analysis, research design, grant writing and technical communication, high creativity and excellent verbal communication skills
• Extensive experience working in cross-disciplinary and translational research projects and teams
• Superior academic record at top biomedical research institutions

A challenging and interesting position as a Senior-level Scientist in a high-growth Maryland-based biotechnology company or institution.

• National Defense Science and Engineering Graduate Fellowship, 2001-2004
• Tau Beta Pi - Maryland Alpha Chapter, National Engineering Honor Society
• Alpha Eta Mu Beta, Biomedical Engineering Honor Society
• Tau Beta Pi Scholarship, 1998
• Society of American Military Engineers Scholarship, 1997
• William Brown Baxley Engineering Scholarship, 1995-1999

1.        Soenen SJH, Himmelrich U, Nuytten N, Pisanic II TR, Ferrari A, De Cuyper M. Intracellular Nanoparticle Coating Stability Determines Nanoparticle Diagnostics Efficacy and Cell Functionality. Small, 6(19): 2136-2145, 2010.

2.        Pisanic II TR, Shubayev VI, Jin S. Iron Oxide Magnetic Nanoparticle Nanotoxicity - Incidence and Mechanisms. Nanotoxicology: From In Vivo and In Vitro Models to Health Risks. John Wiley & Sons, Chippenham. 2009.

3.        Shubayev VI, Pisanic II TR, Jin S. Magnetic nanoparticles for theragnostics. Advanced Drug Delivery Reviews, 61(6): 467-477, 2009.

4.        Pisanic II TR, Blackwell JD, Shubayev V, Fiñones RR, Jin S. Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. Biomaterials, 28 (16): 2572-2581, 2007.

5.        Oh S, Daraio C, Chen LH, Pisanic TR, Fiñones RR, Jin S. Significantly accelerated osteoblast cell growth on aligned TiO2 nanotubes. J. of Biomed. Mat. Res. Part A, 78A (1): 97-103, 2006.

6.        S. Jin and T. R. Pisanic, "Article and Apparatus for Remote Magnetically Induced Treatment of Cancer and Other Diseases, and Method for Operating Such Article", patent filed , 2004.

7.        Ozkan M, Pisanic T, Sheel J, Barrow C, Esener S, Bhatia S. Electro-Optical Platform for the Manipulation of Live Cells. Langmuir 19(5): 1532-1538, 2003.

1R43AI093039-01                       DiIorio (PI)                                                                          02/01/10 - 11/30/11

NIH/NIAID Phase I SBIR

Optimized Magnetic Nanoparticle Labels for Ultra-Sensitive Sepsis Diagnostics

The aim of the program is the development of next generation magnetic nanoparticle labels for ultra high sensitivity immunoassays for pathogenic bacteria.

Role: Principal Assay Development Scientist

AI084298                     DiIorio (PI)                                                                        08/01/09 - 07/31/11

NIH/NIAID Phase I SBIR                     

Ultra-sensitive magnetic assays for quantitative detection of nucleic acids without amplification

The program is centered at developing an ultra-sensitive magnetic assay to quantitatively detect nucleic acids without the need for PCR or other amplification.

Role: Principal Assay Development Scientist

1R43CA134249-01                    DiIorio (PI)                                                                          08/1/08 - 07/31/11

NIH/NCI Phase I SBIR                         

Ultra high sensitivity mix and measure immunoassays in blood

The aim is to develop very sensitive immunoassays directly in blood without any wash steps. 

Role: Principal Assay Development Scientist

9R44CA132533-03                      DiIorio (PI)                                                                        08/01/08-07/31/11

NIH/NCI Phase II SBIR                                   

Nanotechnology based magnetic detection for rare cell assays

(includes 2 year ARRA supplement 3R44CA132533-04S1)

The main goal of this nanotechnology-based program is to develop optimized magnetic sensors and magnetic nanoparticles to permit sensitive cell surface receptor assays on rare cells.

Role: Principal Assay Development Scientist

1R43DK080634-01                     DiIorio (PI)                                                                       09/01/07-08/31/09

NIH/NIDDK Phase I SBIR

Quantitative Intracellular Magnetic Assays on Live Cells

The goal of the program is the development of quantitative intracellular magnetic assays for rapid determination of protein levels in rare cells.

Role: Principal Assay Development Scientist

1R43HL080655-01A1                  DiIorio (PI)                                                                     07/01/05-06/30/06

NIH/NHLBI Phase I SBIR       

In Vivo Molecular Imaging using Magnetic Detection

The aim of the program is the demonstration of in vivo measurement of binding interactions in small animals using magnetic sensors and magnetic nanoparticle labels.

Role: Principal Assay Development Scientist                                                                                         

1 U01 AI066578-01                    DiIorio (PI)                                                                           07/15/05-06/30/09

NIH NIAID  Research Project Cooperative Agreement: Sepsis and CAP 

Ultra-sensitive magnetic assays for sepsis diagnostics

The goal of this program is to develop diagnostic magnetic cell assays for sepsis.

Role: Principal Assay Development Scientist