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Summary

Developmental neurobiologist with 9 years research experience with engineering background. Possess skills to execute projects independently, resourceful in designing new projects, proficient in scientific writing & communication. Experience in studying biological questions using in-vitro, in-vivo and  in-silico tools. Looking forward to develop in-silico models models for better understanding of biological processes and disease models to drive data driven therapeutic strategies. 

Publications

  • Coupling progenitor and neuronal diversity in the developing neocortex. Govindan S, Jabaudon D. Manuscript in revision preparation for FEBBS letter series. 
  • Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex. Telley L*, Govindan S*, Prados J, Stevant I, Nef S, Dermitzakis E, Dayer A, Jabaudon D. Science. 2016 Mar 3. 351 (6280): 1443-6. * Equally contributed to the research. 
  • Migrational speed of Cajal-Retzius cells modulated by vesicular trafficking controls the size of higher-order cortical areas. Barber M, Arai Y, Morishita Y, Vigier L, Gillardeaux PV, Borello U, Contremoulins V, Frank WP, Govindan S, Tissir F, Jabaudon D, Galli T, Pierani A. Current Biology. 2015 Oct 5;  25 (19): 2466-2478
  • Asymmetric cell division of granule neuron progenitors in the external granule layer of the mousem cerebellum. Halipur P, Prakash I, Babu V, Govindan S, Mani S. Biology open. 2015; 4 (7): 865-72
  • Retinal input directs the recruitment of inhibitory interneurons into thalamic visual circuits. Golding B, Pouchelon G, Bellone C, Murthy S, Di Nardo A A, Govindan S, Ogawa M, Shimogori T, Lüscher C, Dayer A, Jabaudon D. Neuron. 2014 Mar 5; 81(5): 1057-69
  • Expression of Sonic hedgehog during cell proliferation in the human cerebellum. Haldipur P, Bharti U, Govindan S, Sarkar C, Iyengar S, Gressens P, Mani S. Stem Cells Dev. 2012; 21(7)
  • Identification of differentially expressed genes involved in Seed Oil Biosynthesis in Jatropha curcas using SSH (Suppression Subtractive Hybridisation). dbEST Citation: Chandran D, Sankararamasubramaniam H.M, Govindan S, Parida A. (2011).

Awards & Grants

  • Swiss Society of Neuroscience Annual Publication award for 2017 awarded at Bern, Switzerland. 
  • IGE3 Student Awards, December 2013 along with 2-year scholarship from IGE3, Geneve, Switzerland.
  • Jean Falk Vairant Award and funding, June 2012 from Lemanic Neuroscience School, Lausanne Switzerland.

Projects

  • Imaging thalamocortical and cortico-thalamic circuitry of Lhx2 Knock out mice. Aiding in data interpretation and protocol establishment for 3D whole brain imaging. Established Collaboration between Prof.Shubha Tole, TIFR, Mumbai, India and Veli-Pekka Ronkainen, Manager, Imaging center, Biocenter, University of Oulu, Oulu, Finland. August 2016 - til date
  • Establishing model system to studying developmental neurological and multi-organ disorders. Establishing primary neuronal cultures, whole brain culture, slice cultures, organ cultures, imaging and in-silico pipelines to study genetic disorders by gain & loss of function experiments. Collaboration with Academy Research Fellow Reetta Hintala, University of Oulu, Oulu, Finland. Jun 2016 - til date. 
  • Lhx2 and its role in cortical development. Identifying Lhx2 dependent cortical development mechanism. Aiding in experimental design, setup and data analysis for transcriptomics and whole brain imaging experiments. Collaboration with Prof.Shubha Tole, TIFR, Mumbai. Dec 2015 - til date.
  • Dissecting the transcriptomic blueprint of neuronal differentiation through real-time singe cell transcriptomics. Independently developed a real time flourescent birthdating technique called "FlashTag". Utilised single cell transcriptomics and performed functional gene analysis through loss or gain of gene function experiments and gene ontology analysis. Prof. Denis Jabaudon Labarotary, Unige, Switzerland. Jun 2012 - Feb 2016. (PhD research work).
  • Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum. Performed histology, live imaging and primary cultures of mouse and human cerebellum.Prof. Shyamala Mani Laboratory, IISc, India. July 2010 to Apr 2012
  • Effect of DC electric field on organotypic cultures of retina for regeneration. Independently designed the project and innovated customized electric chamber to apply electric pulses on organotypic cultures of degenerating retina for regeneration. Performed histology. Prof.Narendra k Dhingra Laboratory, NBRC, India. Aug 2009 - Nov 2009.
  • Identification of oil biosynthetic genes in Jatropha curcas by expressed sequence tag analysis and functional genomics. Performed sanger sequencing of seed stage specific cDNA library preparation and performed in-silico gene function analysis. Supervisor: C  Dr.H.M.Shankararama subramanium, M.S.S.R.F, India. Dec 2007 - Mar 2009

Work History

May 2016Till date
Freelance Research Consultant

June 2012May 2016
Prof.Denis Jabaudon Lab, University of Geneva, Geneva, Switzerland.

Ph.D Scholar

Jul 2010Apr 2012
Prof.Shyamala Mani Lab, Centre for Neuroscience,Indian Institute of Science, Bangalore, India.

Junior Research Fellow

Apr 2009Jun 2009
BiointeQ Bioscience Private Ltd, Chennai, India

Technical Executive

Jun 2008Mar 2009
Biotechnology division, M.S.S.R.F,Chennai, India.

Project Fellow