Project -“ Development of a molecular genetic testing method for Abacavir in Indian population”.
CromDx is unique company bringing Clinician, Physicians and Research community to common platform as stakeholders in advance clinical care requirements of modern era. It is fundamentally a molecular information platform which integrates molecular biology Lab and Clinical/Biological informatics together to develop and launch population specific diagnostics test and prognostics assessments. The project deals with the Development of a molecular genetic testing method for Abacavir in Indian population. Abacavir is a prescription medicine approved by the U.S. Food and Drug Administration(FDA) for the treatment of HIV infection in adults and children 3 months of age and older. Abacavir is always used in combination with other HIV medicines. Abacavir belongs to a class(group) of HIV drugs called nucleoside reverse transcriptase inhibitors(NRTIs). NRTIs block an HIV enzyme called reverse transcriptase. By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body. HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines(called an HIV treatment regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. Individuals with the HLA-B* 5701 allele is found to be more likely to have a hypersensitivity reaction to abacavir. The HLA-B* 5701 allele occurs at a frequency of around five cert in European populations, one pent cent in Asian populations and less than one per cent in African populations. Clinical trials have now shown that screening patients for HLA-B* 5701 before treatment has dramatically reduced the number of side effects being experienced from abacavir use. Abacavir can cause serious, life threatening side effects. These include allergicreactions, lactic acidosis(buildup of acid in the blood), and liver problems. If the individuals found to have the HLA-B* 5701 allele, abacavir is avoided, and alternative HIV treatments are given. The same topic is studied by taking samples(buccal swab) from few people and its DNA was extracted followed by PCR optimization and Sequencing