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Postdoctoral Fellow
Worked with Nobel Laureate Professor Herbert C. Brown
- Asymmetric Synthesis via Organoboranes
Worked with Nobel Laureate Professor Herbert C. Brown
- Asymmetric Synthesis via Organoboranes
Synthesis Support Group (Team Leader): Directed and performed the rapid lab development of scalable chemical processes followed by timely delivery of multi-gram to kg amounts of API/intermediates in support of safety assessment, formulation development and Phase I trials under GMP conditions. Effectively delegated work assignments and allocated resources to meet aggressive project timelines of high-priority clinical candidates.
Independently designed, optimized and executed highly efficient processes for the synthesis of challenging target molecules. Developed robust new methodologies and demonstrate viability on kg-scale. Oversaw technology transfer to pilot plant and manufacturing facilities. Managerial and mentoring responsibility for B.S./M.S. and Ph.D. chemists.
Technical Operations/Manufacturing Division
Provided technical expertise and support for in-line manufacturing processes; developed rework solutions for out-of-spec batches. Oversaw technology transfer from laboratory to pilot plant and manufacturing facilities. Developed new syntheses of clinical candidates emanating from joint ventures.
Thesis Title: "The Organic Chemistry of Phosphenium Ions"
API process development/optimization
Technology transfer to CRO’s and JV’s partners
Implementing Green Chemistry principles
Regulatory compliance (GMP)/CMC preparation
Scale up to pilot and commercial venues
Troubleshooting manufacturing processes
Modern homogeneous catalysis
Statistical Design of Experiments
Automation tools for research
Pre-clinical drug development
Discovering new methodologies
High-throughput screening
Accomplished PhD organic chemist with small-molecule pharmaceutical expertise in process research, API manufacturing and preclinical development.
Proven ability to successfully lead and collaborate within an interdisciplinary team or matrix organization comprised of analytical chemists, chemical engineers, project team members, regulatory, legal and manufacturing personnel.A prolific record of developing innovative solutions to challenging chemical problems as evidenced by being:An Inventor on 8 U.S. patentsAn Author of 30 peer-reviewed journal articlesA Recipient of the Merck Special Acheivement Award: 2007An Invited lecturer at 8 Universities/Colleges
Specialties:Process Optimization ● Route Selection ● Technology Transfer ● High Throughput Screening ● Scale-up Design of Experiments ● Green Chemistry Principles ● API Manufacturing ● Pre-clinical Development ● Regulatory Compliance ● Project Leadership ● Potent Compound Handling ● Homogeneous Catalysis
Group leader/Senior Scientist position in Process Chemistry or Manufacturing Operations at a small-molecule pharmaceutical company or CRO where my expertise in developing and implementing robust syntheses of clinical candidates is a core responsibility.