Rania Hamdy



Work History

Work History
Nov 2014 - Nov 2015


part time trainer

Chemical course

  1. Chemical Laboratory Operations, Equipment, Instruments.
  2. High performance liquid chromatography
  3. Water analysis and quality control
  4. Drug design
2013 - 2014

lecturer of Medicinal Chemistry 

Zagazig university -Egypt 
2009 - 2011

Assistance lecturer of Medicinal Chemistry 

2007 - 2008

Quality control pharmacist


Pass the MOH (ministry of health) exam in Dubai and work at Med Pharma          Pharmaceutical Company at quality control department for 6 months. Experience the using of HPLC and GC for monitoring of bulk products,   Finished products and follow up the registration of new pharmaceutical products Work at Gulf pharmacy RAK for 6 months.

2002 - 2006

Demonstrator in Medicinal

 Demonstrator in Medicinal Chemistry Department, Faculty of

Pharmacy, Zagaig University, Zagazig, Egypt



Sep 2009 - May 2013


faculty of pharmacy

May 2013                   PhD of Pharmaceutical Sciences in Medicinal Chemistry, Faculty of


Pharmacy, Zagazig University.


April 2012             : PHD of Pharmaceutical Sciences in Medicinal Chemistry at Cardiff


University (practical work)


Title of PhD thesis:  Design and synthesis and biological evaluation of a novel anti- apoptotic Bcl-2 inhibitor under joint supervision between Egypt and Cardiff as channel  program scholarship  holder  work  at Dr Andrew Westwell the chemistry part and the tissue culture at Dr Arywn Jones laboratory

1998 - 2007

B.S.c and master degree 


University Graduation Degree and Specialization


1998-2002:                 Study of Pharmacy, Faculty of Pharmacy, Zagazig University.


May 2002 :                 B.Sc.  of Pharmaceutical Sciences  with general grade “Excellent with Honors”.

2003-2004:                  Pre-Master courses.


Jan 2007  :                  Master   of   Pharmaceutical   Sciences   in   Medicinal   Chemistry, Faculty of Pharmacy, Zagazig University.

Title of M.Sc. thesis:  Synthesis of novel 2-arylquinoline-4-carboxylic acid derivatives for potential biological activities.



The experience of modern organic synthesis, the use of different purification methods and identifying compound structure using different analytical methods such as MS, NMR, IR and micro analysis.

  • Extensive knowledge of the drug-like properties and how to apply those for a designed compound prior to synthesis.
  • Synthesis of different heterocyclic systems for different biological targets:quinolines, pyrazoles, indoles, oxadiazoles, thiadiazoles, triazoles,triazolethiadiaoles

  • Expert in different purification techniques for compounds specially crystallization and column chromatography.
  • Molecular modeling using MOE and FlexX.


  • Expert in performing a variety of in vitro growth inhibitory assays (MTT and CTB biochemical assays) and binding assays applying ELISA and manipulation of the data using different software's: Excel, and Graph pad Prism

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                                   Metwally K. A, Abdel-Aziz L. M, Lashine E. M, Husseiny M. I. and Badawy  R.  H.  Hydrazones  of  2-aryl-quinoline-4-carboxylic  acid hydrazides:Synthesis and  preliminary evaluation as antimicrobial agents.Bioorganic&Medicinal Chemistry 2006,14 (24) 8675-8682.


Rania Hamdy, Noha Ziedan, Mohamed El-Sadek, Elsaid Lashin, Andrea Brancale, Arwyn T. Jones and Andrew D. Westwell. Synthesis and evaluation of indolyltriazol- amines as Bcl-2-inhibitory anticancer agents. Bioorganic & Medicinal Chemistry Letters, Volume 23, Issue 8, 15 April 2013, Pages 2391-2394


Design, Synthesis, and Evaluation of Novel Indole-3-yl-1,3,4-oxadiazoles and Their Derivatives as Bcl-2 Inhibitors with Antitumor Activity (submitted)

Synthesis and evaluation of quinoline-based oxadiazoles as Bcl-2 inhibitors anticancer agents (submitted)

Virtual screening, SAR and discovery of 5-(indol-3-yl) -2-[(2-nitrophenyl)amino] [1,3,4]-oxadiazole as Novel Bcl-2 inhibitor(under submission )

Synthesis and biological evaluation of 2-(4-(aryl)-5-(1H-indol-3-yl)-4H-1,2,4-triazol-3-ylthio)-N-(aryl)acetamide as Bcl-2 inhibitors (under submission)

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Computer skills:








Microsoft applications (Word, Excel, Internet, PowerPoint).



ACD labs (Chem.Sketch, HNMR, Name, Log p)



Chem office (draw)



Molecular docking programs (MOE and FLEX-X )



Graph pad prism 6 for statistical calculation of IC50



Endnote reference management program.

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Professional development


I have developed my professional skills and abilities through attendance of the professional development programs at faculty and leadership development center (FLDC) Zagazig University, Egypt

  • Credit hours system (FLDC , 2008)
  • Paper writing and publication (FLDC , 2009)
  • Student evaluation and examination techniques ( FLCD, 2009)
  • University, financial aspects (FLDC , 2009)
  • Legal aspects in university environment (FLDC , 2009)
  • Lecturer preparation course (FLDC , 2009)
  • Quality, Academic standards, Presentation skills, Effective communication during crises and Ethics of Scientific Research 2012
  • Mastering people management and teamwork leadership
  • Communication skills in business
  • Organization competency
  • Innovation and development
  • Strategic planning (FLDC, 2013)
  • Quality management (FLDC, 2013)
  • IT workshop (excel, word, powerpoint, photoshop) (FLDC.2008)

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Egyptian government channel scheme scholarship for a practical PhD work in the UK


Awarded an EORTC-PAMM fellowship in order to allow you to attend the 2013 PAMM


meeting in Cardiff- United kingdom .



Oral presentation the Jan 2013 PAMM meeting in Cardiff- United Kingdom. Attending second scientific harvest zagazig university March 2013

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Dr. Andrew Westwell, Senior lecturer in Medicinal Chemistry.

Postal Address: Cardiff School of Pharmacy and Pharmaceutical Sciences

Telephone: 02920875800; Email:  westwella@cf.ac.uk

Dr Arwyn Tomos Jones,Reader in Membrane Traffic and Drug Delivery postal address Cardiff School of Pharmacy and Pharmaceutical Sciences Email: jonesat@cardiff.ac.uk

Prof. Mohammed Al-Sadek, Professor of Medicinal Chemistry.

Postal Address: Zagazig University, Faculty of Pharmacy, Zagazig, Egypt

Telephone: 00201009581731; Email: alsadek.mohammed@yahoo.com


Prof. El Said Lashin, Professor of Medicinal Chemistry.

Postal Address: Zagazig University, Faculty of Pharmacy, Zagazig, Egypt

Telephone: 0020128011; Email: Elsaidlashin@yahoo.com

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