To find a position utilizing my extensive scientific knowledge, management and communication skills to liaise effectively between academia and industry, identify and promote the adoption of novel and emerging therapies and diagnostic tools, and empower and enhance the knowledge of end-users within the medical community.
- Over 20 years academic research experience in cancer genetics, hemopoietic malignancies and stem cell biology.
- Extensive research and clinical collaborations with a broad range of academic research and clinical personnel.
- Secured more than $3,000,000 in research funding.
- Published more than 20 manuscripts in high impact journals.
- Presented research findings at more than 75 national and international conferences.
- Mentored and supervised MSc and PhD graduate students.
- Critically evaluated scientific literature and conducted comprehensive literature searches.
- Managed multiple research projects throughout lifecylce - responsible for strategic planning, problem solving and troubleshooting, consensus building and managing project budgets.
- Proven ability to establish and maintain productive collaborations and coordinate and lead multicentre projects.
- Ability to prioritize and manage multiple concurrent competing priorities.
- Development and implementation of education and training strategies.
- Strong supervisory skills based on a philosophy of team building and facilitation of individual strengths.
- Proficient in Outlook, PowerPoint, Excel, and Word software programs.
Jun 2002 - Present
Research Scientist, Principal Investigator
- Responsible for management of research projects from inception to publication.
- Directed research in areas of oncology, cancer genetics, cell biology, immunology, cardiac stem cell therapy.
- Developed and used preclinical animal models to assess therapeutic efficacy of gene and stem cell therapies
- Application of microarrays for gene expression profiling and the identification of biomarkers.
- Experience with small molecule inhibitors
- Secured continuous funding for all research through submission of grant applications
- Supervision of Postdoctoral Fellows, Graduate Students, Summer Students and Research Associates.
- Publication of more than 20 manuscripts in high impact journals.
- Oral presentations of research findings at international, national and local conferences.
- Established collaborations with clinicians, research scientists and veterinarians.
- Review of research grants and proposals including analysis of budget requests
- Worked with Tech Transfer personnel on patent applications.
Jan 2000 - Present
University of Toronto
- Mentorship of graduate students, undergraduate students and summer students
- Course coordinator for a graduate level course in Translational Research in Pathobiology.
- Lectured in undergraduate and graduate level courses: Genes, Genetics and Biotechnology (4th year), Introduction to Pathobiology, Molecular Biology Techniques (graduate)
- Graduate Student Committee Member for numerous M.Sc. and Ph.D. students
- Internal and External Departmental Thesis Examiner
- Committee member for peer review of research grant proposals submitted to the Canadian Institutes of Health Research and Heart and Stroke Foundation
- External review of research grant proposal
Jul 1996 - Jun 2002
Sunnybrook Health Sciences Centre
- Conducted research aimed at deciphering the role of the homeodomain containing transcription factor HOX11 in the initiation and progression of lymphoma.
- Used a transgenic mouse model to develop dendritic cell based immunotherapy for the treatment of lymphoma.
- Expertise in flow cytometry, immunohistochemistry, histology, retroviral infection, molecular biology, PCR, RNA and Protein expression analysis.
- Co-supervised research projects to develop gene therapy protocols for the treatment for lysosomal storage diseases using the preclinical canine model of Mucopolysaccharidosis I (MPSI).
- Established collaborations and liaised with clinicians and other research scientists.
- Secured peer-reviewed funding to support all ongoing research projects.
- Presented research findings at international conferences.
Jan 1990 - Apr 1996
Terry Fox Laboratory, B.C Cancer Agency
- Established the transgenic mouse facility.
- Generated multiple transgenic mouse lines to assess the role of genes in hemopoiesis.
- Used retroviral infection of hematopoietic stem cells to assess the role of homeodomain-containing transcriptions factors in normal and malignant hemopoiesis.
Sep 1985 - Jan 1990
- Analysis of the role of genomic instability in the progression of melanoma using cytogenetic and molecular approaches.
- Expertise in cancer genetics, cytogenetics, molecular biology, tissue culture.
- Supported by NSERC and OGS scholarships for the duration of my Ph.D. studies.
Sep 1982 - May 1985
- Academic focus in medical genetics, cancer genetics, cell biology, molecular biology, cancer initiation and progression.
Research and Grant Proposal Development
Secured continuous funding to support ongoing research for 1999 to present National Cancer Institute-Canada: 1999-2005; $722,575 Medical Research Council-Canada: 1999-2004; $326,600 Canadian Institutes of Health Research: 2002-2011; $1,242,136 Cancer Research Society: 2006-2010; $240,000 Heart and Stroke Foundation 2005-2010; $433,839
Writing and Communication
Published more than 20 manuscripts in high impact journals including J Exp Med, Immunity, PNAS, Oncogene and Stem Cells. More than 75 presentions of reseach findings at national and international conferences
Adhoc Review of Manuscripts and Conference Abstracts
Journals Oncogene, Leukemia, Leukemia Research, Leukemia and Lymphoma, Haematologica, Experimental Hematology, British Journal of Hematology, Hematology Reviews, Molecular Therapy, Molecular Reproduction and Development. Abstracts American Society of Hematology: Abstract Peer Review Panel; Gene Therapy.
Member of Research Grant Review Panel
Reviewed research proposals and budget requests submitted to granting agencies. Generated reports for each grant detailing strengths and weaknesses. Ranked grants and participated in discussions to determine which grants would be funded. Review Panel Member for: Heart and Stroke Foundation of Canada Peer Review Committee: Integrative Studies; genetic manipulations, imaging, bioengineering. Canadian Institutes of Health Research Peer Review Committee: Molecular and Cellular Biology of Cancer Canadian Institutes of Health Research Selection of Peer Review Committee: Molecular and Cellular Biology of Cancer Adhoc Review of Grants and Fellowships for: National Cancer Institute of Canada, Cancer Research Society, Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, Wellcome Trust, American Kennel Club
Flow Cytometry FACScan flow cytometer operation, 9-colour flow cytometric analysis, data interpretation. Cell cycle analysis Tissue Culture Derivation of canine embryonic stem cell lines Assessment of small molecules to optimize culture conditions Long-term culture of hemopoietic cells OP9DL1 co-culture of thymocytes Maintenance of stable cell lines Isolation of bone marrow derived dendritic cells Maturation of dendritic cells for antigen presentation Immunology Assays CTL, MLR assays T-cell and B-cell proliferation assays Antibody purification and labelling with fluorescent dyes Cytogenetics G-banding, Q-banding, karyotype analysis In situ hybridization for gene mapping Molecular Biology Cloning, Southern, Northern, Western Analysis PCR, RT-PCR, qRT-PCR analysis Microarray and gene expression profiling Generation of transgenic mice