Work History

Work History
Jul 2010 - Present

Associate Professor

Sechenov First Moscow Medical University

Associate Professor at Department of Public Health and Preventive Medicine, Faculty of Public Health Management and Economics

Nov 2010 - Present

Head of Clinical Studies and Monitoring Department

Valenta Pharm JSC
Jan 2010 - Oct 2010

Deputy Medical Director (CRA)

AVVA RUS JSC

Main responsibilities:

- participation in assessment of necessity and applicability of Clinical studies of medicines in appropriate groups of patiients;

- development of clinical trials' Protocols, Investigator's brochures, Informed concents, Case-report forms etc. (Phases I-III);

- development of sets of documents for State registration of Clinical trials' Protocols and Reports (in Russia, Ukraine, EU);

- participation in monitoring and evaluation of clinical trials (including ones of bioequivalence studies);

- clinical trials' data analysis;

- creating Final reports and articles/papers representing results of clnical trials; 

 - writing Literature Reviews about potential clinical effectiveness, safety, cost-effectiveness of appropriate medicines and their pharmacological groups or subgroups, their application in USA, countries of EU etc.; 

- negotiating with stakeholders (Centers, Investigators, Authorithies) in Russia, CIS, EU.

Sep 2006 - Jul 2010

Executive director

Russian Society of Evidence-based medicine specialists

Main responsibilities:

- organizational management (regional promotion, development of membership system and communication between regional branches etc.);

- website development;

- mass mailing (information to stakeholders);

- project management (see Constancies);

- development and carrying-out trainings in EBM, clinical epidemiology and biostatistics (see Constancies);

- antitobacco and antialcohol lobbying in Russia.

Oct 2004 - Nov 2005

Head of the Biostatistics Panel

Learning resource center of Stavropol State Medical Academy

Education

Education
Oct 2008 - Sep 2009

Master of Public Health (MPH)

Hebrew University of Jerusalem

International Master of Public Health Program at Hebrew University of Jerusalem-Hadassah Joseph H. and Belle R. Braun School of Public health and Community medicine, Jerusalem, Israel.

MPH Thesis’ topic: "Empirical assessment of alcohol consumption effects on labor productivity and income level in Russia".

Focus on: Epidemiology, Health Econpmics, Biiostatistics, Demography, Communicable diseases, Health management, Public Health and Healthcare programs monitoring, evaluation and implementation, Prioretization in Public Health, Health Systems, Health Technologies assessment (HTA), International Public Health, Health nutrition,  Health Sociology, Health promotion and behavior, HIV/AIDS, Project and organizational management.

Sep 2005 - Sep 2008

Philosophy Doctor (PhD)

National Research Center Institute of Immunology FMBA of Russia

Title of  the PhD Research "Development of new murine model of bronchial asthma induced by timothy pollen allergen".

Publications (selected):

Kryuchkov NA, Babakhin AA, Bashkatova YuN, Khaitov MR. A novel acute murine model of bronchial asthma induced by timothy pollen allergen without adjuvant. Allergy 2009.

Kryuchkov NA, Bashkatova YuN, Khaitov MR, Litvin LS. IgE immune response in vivo to timothy grass allergen. Allergy 2008; 63(Suppl 88):256.

Kryuchkov NA, Babakhin AA, Bashkatova YuN et al. An acute mice model of IgE-mediated bronchial asthma induced by timothy pollen allergen: final results [Article in Russian]. Rus Allergol J 2008; (4):37-45.

Kryuchkov NA, Babakhin AA, Khaitov MR. Mouse models of bronchial asthma: the general principles and profit [Article in Russian]. Phys Pathol Immune System 2008;(3):3-7.

Nov 2006 - Dec 2006

Specialist in Evidence-based medical practice and Biostatistics

St. Petersburg Medical Academy for Postgraduate Studies

Faculty: Department of Public Health

This course included several subjects: Evidence-Based Medicine, Introduction to Epidemiology, Biostatistics, Data analysis using SPSS.

Participation at conferences/events (selected)

2010, September - reporter, Round table "Antitabacco legislation in Russia: the history, international experience, future", World Bank, Moscow, Russia.

2010, August - poster presentation, International Congress of Immunology (ICI 2010), Kobe, Japan.

2010, June- lecturer and workshop chairman, Summer School for Researchers, MPH and PhD students, Sechenov First Moscow Medical University, Harvard School of Public Health, Moscow, Russia.

2010, April – lecturer in immunology and clinical epidemiology, Education Course on Neuroophtalmology for ophthalmologists, Academician S.N. Fyodorov Russian Federal State institution The Intersectional Scientific and Technological Complex “Eye Microsurgery” of Federal Agency of High Technology Medical Assistance, Moscow, Russia.

2008, August – chairman and senior lecturer, Educational course for clinicians, researchers, public health managers and university lecturers “Biostatistics and clinical epidemiology”, Russian society of Evidence-based medicine specialists, Bashkir State Medical University, Ufa, Russia.

2008, June – reporter, XXVII Congress of the European Academy of Allergy and Clinical Immunology (EAACI 2008), Barcelona, Spain.

2008, June – co-chairman, Workshop on epidemiology, descriptive statistics and presentation of scientific reports, NGO “Public health development”, St. Petersburg, Russia.

2008, May – lecturer in immunology and clinical epidemiology, Education Course on Neuroophtalmology for ophthalmologists, Academician S.N. Fyodorov Russian Federal State institution The Intersectional Scientific and Technological Complex “Eye Microsurgery” of Federal Agency of High Technology Medical Assistance, Moscow, Russia.

2008, February – reporter, Workshop “EBM and health care quality”, Russian society of Evidence-based medicine specialists, Bashkir State Medical University, Ufa, Russia.

2007, November – participant, Russian-Israeli Workshop “Migration and Public health”, Russian society of Evidence-based medicine specialists, Open health institute, Hebrew University of Jerusalem-Hadassah Joseph H. and Belle R. Braun School of Public health and Community medicine, Jerusalem, Israel.

2007, September – reporter, II International Congress “Immune-mediated diseases: from theory to practice” (IMD-2007), Moscow, Russia.

2007, May – reporter, Russian Congress RAACI, Moscow, Russia.

2007, May – lecturer in immunology, Education Course on Neuroophtalmology for ophthalmologists, Academician S.N. Fyodorov Russian Federal State institution The Intersectional Scientific and Technological Complex “Eye Microsurgery” of Federal Agency of High Technology Medical Assistance, Moscow, Russia.

2007, April – reporter, workshop co-chairman, XIV Russian Congress “Man and drug”’, Moscow, Russia.

Volunteer experience, honors

Member of Russian Society of Evidence-based Medicine specialists (RusEBMS) and European Academy of Allergy and Clinical Immunology (EAACI), The Cochrane Collaboration. 

Winner of travel grants and fellowship from EAACI (2008), Hebrew University of Jerusalem/The Legacy Heritage Fund (2008), American Association of Immunology/International Congress of Immunology (2010), scholarships from Mayor of Stavropol (1998) and Governor of Stavropol region (1998-1999). Winner of awards at the International Conferences for Young Researchers "Step into the future" (1998), "Space" (1999) and 6 other Russian and regional Conferences.

Constancies (selected)

2008 - 2010 – consultant of CROs and Pharmaceutical companies in registration of medicines and clinical studies (protocols, reports) in Russia and Ukraine.

2008, May - 2009, March – Head of Project “Education in Biostatistics in Russia”, Russian society of Evidence-based medicine specialists.

2007, November - 2008, June – member of supervisor team at Project “Training in epidemiology and report presentation”, NGO “Public health development”.

2007, October - 2008, April – lead manager of Project “Migration and public health in Russia”, Russian society of Evidence-based medicine specialists and Open health institute.

2006, October - 2007, November – Head of Project “EBM recommendations for HIV-positive people and providers of HIV/AIDS services”, Russian society of Evidence-based medicine specialists.

2006, May – author and editor, multimedia educational course on biostatistics (was recommended by Organizational and methodological union of Russian High schools on medical and pharmaceutical education for medical under- and postgraduates), Moscow, Stavropol, 2006.

2006, April – head administrator, International symposium ‘Health system development’, HSD international program, Moscow, Russia.

2006, February – lead organizer, II Conference of Russian Society of Evidence-based medicine specialists, St. Petersburg, Russia.

2005, February - 2005, June – senior lecturer in Biostatistics and Medical informatics, Learning resource center, Stavropol State Medical Academy, Stavropol, Russia.

2004 - 2010 – research consultant (preparation of protocols and reports, data analysis), 32 studies in the area of immunology, clinical endocrinology, internal medicine, public health, epidemiology, 18 of which - Candidate and Doctoral Theses. 

Summary

Degrees: Medical doctor (M.D.), Specialist in Evidence-based medical practice, Candidate of Medical Sciences (K.M.N., Russian Ph.D. equivalent), Master of Public Health (M.P.H., Hebrew University of Jerusalem).

Areas of activities: biostatistics, evidence-based medicine, health technology assessment, clinical studies, epidemiology and research methodology, HIV/AIDS, non-communicable diseases, demographic aspects of public health, animal models for studies of allergic diseases, innate immunity. 

Publications (selected)

Kryuchkov NA. Pathogenetic perspectives of bronchial asthma: review [Article in Russian]. Vestn Ross Akad Med Nauk 2010;(8):46-51.

Kryuchkov NA, Bashkatova YuN, Khaitov MR. Murine models of atopic bronchial asthma: methodology and prospects of application [Article in Russian]. Vestn Ross Akad Med Nauk 2010;(7):22-28.

Kryuchkov NA, editor, Kornisheva EA, Gill AYu, Vlassov VV et al. HIV infection and AIDS. Evidence-based guidelines for providers of services and people living with HIV/AIDS. Moscow (Russia): RusSEBMS, OHI; 2009.

Kryuchkov NA, Babakhin AA, Bashkatova YuN, Khaitov MR. A novel acute murine model of bronchial asthma induced by timothy pollen allergen without adjuvant [Abstract]. Allergy 2009.

Bashkatova YuN, Petrukhina A, Andreev SM, Kryuchkov NA, Khaitov MR. An assay to detect IL4d2 [Abstract]. Allergy 2009.

Kryuchkov N, Danishevskiy K, Vlassov V, Rafalskiy V, Gill A . [P01-7] The Cochrane Library as a basic source for development of EBM guidelines for people living with HIV/AIDS: Russian experience. 16th Cochrane Colloquium, Freiburg, 3-7 October 2008.

Kryuchkov NA, Danishevskiy KD, Vlassov VV et al, OSDM Task Force. The development of EBM guidelines for people living with HIV/AIDS and HIV services: the Russian experience. In: Proceedings of the AIDS 2008 - XVII International AIDS Conference: Abstract no. CDD0474. Mexico, 2008.

Amlaev KR, Kryuchkov NA. HIV/AIDS perception and risk behavior among high school students in the Stavropol region of Russia. In: Proceedings of the AIDS 2008 - XVII International AIDS Conference: Abstract no. CDC0394. Mexico, 2008.

Amlaev KR, Kryuchkov NA. EBM review and recommendations: the impact of tobacco smoking, nutrition and insolation on health of people living with HIV/AIDS. [Article in Russian]. Prevention of diseases and healthcare [Profilaktika zabolevaniy I ukrepleniye zdorov’a] 2008;(5):10-15.

Kryuchkov NA, Bashkatova YuN, Khaitov MR, Litvin LS. IgE Immune response in vivo to timothy grass allergen. Allergy 2008; 63(Suppl 88):256.

Kryuchkov NA, Babakhin AA, Bashkatova YuN et al. An acute mice model of IgE-mediated bronchial asthma induced by timothy pollen allergen: final results [Article in Russian]. Rus Allergol J 2008; (4):37-45.

Kryuchkov NA, Babakhin AA, Kozmin LD et al. Development of IgE-dependent bronchial asthma model using laboratory animals with timothy pollen allergen [Abstract in Russian]. Rus Immmun J 2008;(4).

Kryuchkov NA. Migration and public health [Article in Russian]. News Tech Modern Med 2008;(1): 8-10.

Kryuchkov NA, Babakhin AA, Khaitov MR. Mouse models of bronchial asthma: the general principles and profit [Article in Russian]. Phys Pathol Immune System 2008;(3):3-7.

Kryuchkov NA. MHC-peptide tetramers using for detection of T-cell antigen-specific populations [Article in Russian]. Immunologia 2008;29(3):187-90.

Kryuchkov NA, Babakhin AA, Khaitov MR, Martinov AI. Adjuvant-free mouse model of bronchial asthma on causally relevant G6 allergen [Abstract]. In: Proceedings of the II International Congress “IMD 2007”, Moscow, Russia, 2007.

Kryuchkov NA, Khaitov MR, Alexeev LP. Multimeric MHC-peptide complexes: biomedical application [Abstract]. In: Proceedings of the II International Congress “IMD 2007”, Moscow, Russia, 2007.

Kryuchkov NA, editor, Pivovarov YuV, Tekeeva AA. Education course on Biostatistics. [CD-ROM]. Moscow, Stavropol (Russia):RusEBMS; 2006. Recommended by Organizational and methodological union of Russian High schools on medical and pharmaceutical education for medical under- and postgraduates.

Vodolazhskaya MG, Kryuchkov NA, Shekhovtsova KV. Autochronometric abnormalities in patients with cerebral pathology in various locations. Neurosci Behav Physiol 2004;34(7):649-58.

Vodolazhskaya MG, Kryuchkov NA, Shekhovtsova KV. Auto-chronometric abnormalities in patients with various location of cerebral pathology [Article in Russian]. Zh Nevrol Psikhiatr Im SS Korsakova 2003;103(5):26-33.

Kryuchkov NA. The computer method of autochronometric evaluation in healthy people and patients with cerebral pathology [Article in Russian]. In: Articles of the X International science conference “Cycles in nature and society”; vol 1; Stavropol, Russia; 2000.

Skills

Skills

Clinical trial-related competencies

- Preparation of a set of documents for conducting of clinical trials (CTs), phases I-IV in Russian and English; - Registration of clinical trials' documents (protocols, ICF, CRF, IB, final reports etc.) in Russia, Ukraine, Belarus; - Development of CTs' protocol from idea (including all methodological issues); - Seeking for trial sites; - Negotiation with state authorities, investigators, sponsors; - Monitoring of CTs; - Statistical analysis of CTs' data.   

IT skills

- Professional system administration of workstations and servers (OS MsWindows 9x, NT, 2000, XP, Vista, 7, MsDOS, MacOS 10); - Assembling and service of PC; - Use of program packages for data analysis and data mining (SPSS 13.0-16.0, Statsoft Statistica 6.0-7.0), soft for epidemiological data preparation and analysis (WinPepi, EpiInfo, EpiData), other soft (MsOffice, CorelDraw, Adobe Photoshop etc.); - Basic and intermediate skills in programming (Qbasic, Ms Visual Basic, Ms Visual FoxPro). 

Language skills: Russian - native

Language skills: English - fluent