Screened anti-histamine new chemical entities (NCEs) through the use of animal models including induced bronchospasm, histamine-induced paw edema, and compound 48/80 (mast cell degranulator).
- Inflammation and Ulcerogenicity
Performed anti-inflammatory NCEs screening via carrageenan-induced paw edema, cotton pellet granuloma, and lipopolysaccharide induced TNF-alpha levels in mice. Explored anti-ulcerogenic activity via indomethacin-induced ulcerogenic activity.
Screened anti-cancer drug formulations by tumor induction in Balb/c mice with cell line; performed tumor regression studies.
- Cardiovascular measurements & safety pharmacology
Conducted safety pharmacology studies including measurement of blood pressure by telemetry method, the spontaneous motor activity of mice, and barbiturate-induced sleeping time.
- Drug Metabolism by Cytochrome P450 enzyme
Induced Cytochrome P450 enzymes in rats and prepared microsome.
- Directed in vitro and in vivo assay optimization and reproducibility with a focus on cost efficiency and time constraints. Preplanned and executed experiments with intense precision, documentation, and methodology improvement with each iteration. Established reliable, easily reproducible assays for the screening of new drug entities (NCE’s) anti-histaminic, anti-inflammatory drugs and anti-cancerous drug formulations.
- Proactively gathered information and developed understanding of different research areas to acclimate quickly and contribute to new experiments. Shared knowledge and experience with the junior
- Utilized strong multi-tasking ability to prioritize and balance numerous simultaneous experiments. Ensured consistently available reagents and comprehensive, organized, and easily accessible documentation in conjunction with skillful time and resource management to attain a high degree of workplace efficiency.
- Determined efficacy, potency, and cardiovascular safety through pharmacological studies and drug-drug interaction studies of selected NCEs; compiled data, performed analysis and generated reports.
- Followed good laboratory practice (GLP) guidelines to carry out experiments in a timely fashion and fill new drug entities for Phase I clinical trials. Appraised senior management regarding progress.
- Quickly promoted from trainee research assistant to research officer in just three years as a result of excellent performance.