- STRASBOURG France
Postdoctoral project in relation with PhD subject. Redaction of the scientific articles
Doctoral thesis preparation within a joint PhD program in Membrane biophysics between University of Strasbourg and the University of Basel (Biozentrum).
The goal of my PhD project was providing better understanding of the interaction between cationic amphipathic peptides with model membrane and nucleic acid, and the mechanism of gene delivery by those peptides, which will allow the development of more efficient peptide-based transfection agents. The thermodynamic and structural parameters of such interaction were established.
Responsible for interpretation of NMR flash analysis data and attributing the compound quality labels
Synthesis of building blocks for screening collection
Thesis title : Investigations of the membrane and nucleic acid interaction of the designed transfection peptide LAH4L1. Molecular mechanisms of complex formation and cellular entry
Organic chemistry. Degree with honour.
Thesis title : Reduction of 3-substituted isocoumarins for the synthesis of natural compound analogues
Spectroscopy : solid and liquid-state NMR,circular dichroism, fluorescence absorption; isothermal titration calorimetry, particle size determination (DLS); peptide synthesis and purification, organic synthesis.
Protein expression, mass spectrometry (MALDI), protein structure calculation
Working with scientific databases, aggregation and analysis of research data
Oral and written communication of research results (presentation at scientific conferences, editing articles for science journals, writing PhD thesis);