Mark Hance

Work History

Work History
Mar 2008 - Present

Bioinformformatics Scientist

Astrazeneca Pharmaceuticals

·Extensive use of SQL Developer, Quosa, I2E Linguamatics,

·Experienced in Perl, R, Java, ORACLE, SQL, and Unix

·Constructed internal Oracle database for Hepatotoxicity Knowledgebase (HKB) for the collection and analysis of assertions from preclinical studies relevant to hepatotoxicity.

·Performed gene-expression and pathway network analysis for the selection of potential biomarker candidate proteins for compound-induced seizure.

·Compiled compound hepatotoxicity profiles for use in translational medicine hepatotoxicity studies.

·Conducted text mining, network analysis and machine learning analysis for prediction and classification of antipsychotic compounds as to propensity to induce metabolic syndrome.

·Produced safety assessment profiles for dopamine receptor species variability and tissue-specific expression to highlight potential toxicity issues.

·Perfomed text mining and literature curation operations to support Hepatotoxicity Knowledgebase (HKB), seizure biomarkers, metabolic syndrome, cardiotoxicity, and other safety-related projects to provide decision support information to safety and CNS scientists.

Mar 2005 - Jul 2007

Research Faculty/Computational Biologist

Virginia Bioinformatics Institute

·Performed bioinformatic software analysis for the development of a cyberinfrastructure, including genomic and protein annotation tools, phylogenic analysis, pathway prediction and visualization, host-pathogen interaction visualization and linking to a wide assortment of experimental datatypes.

·Developed a computational pipeline for the selection of potential vaccine targets in microbial pathogens.

·Instrumental in the development of a computational gene and protein annotation pipeline for the annotation of bacterial and viral genomes.

·Worked on analysis and implementation of molecular pathway prediction and visualization tools for the Pathogen Resource Information Center (PATRIC) at VBI.

Education

Education

Bachelor of Science

Old Dominion University

I attended Old Dominion University after being honorably discharged from the U.S.Navy.  I majored in Biology, with a special interest in neurobiology and genetics. I minored in English with a concentration on classic literature and poetry.

Jan 2001 - Jan 2004

Masters in Biotechnology/Bioinformatics

Johns Hopkins University