·Extensive use of SQL Developer, Quosa, I2E Linguamatics,
·Experienced in Perl, R, Java, ORACLE, SQL, and Unix
·Constructed internal Oracle database for Hepatotoxicity Knowledgebase (HKB) for the collection and analysis of assertions from preclinical studies relevant to hepatotoxicity.
·Performed gene-expression and pathway network analysis for the selection of potential biomarker candidate proteins for compound-induced seizure.
·Compiled compound hepatotoxicity profiles for use in translational medicine hepatotoxicity studies.
·Conducted text mining, network analysis and machine learning analysis for prediction and classification of antipsychotic compounds as to propensity to induce metabolic syndrome.
·Produced safety assessment profiles for dopamine receptor species variability and tissue-specific expression to highlight potential toxicity issues.
·Perfomed text mining and literature curation operations to support Hepatotoxicity Knowledgebase (HKB), seizure biomarkers, metabolic syndrome, cardiotoxicity, and other safety-related projects to provide decision support information to safety and CNS scientists.