Objective

Dynamic Biotech/Pharmaceuticals Executive with a track record in biotech, genome and drug discovery and development with experience in rapidly advancing biologics from research through clinical and commercial stages.

Interest

Custom

AWARDS AND HONORS: • A fellowship from Austrian Ministry of External Affairs, AUSTRIA from January 1985 to May 1988. • Who’s Who Environmental Registry, 1992. Publications: 30 Publications, 37 Patents and Patents Applications, 8 Talks given at Conferences and Institutions.

Summary

Dynamic Biotech/Pharmaceuticals Executive with a track record in biotech, genome and drug discovery and development with experience in rapidly advancing biologics from research through clinical and commercial stages. Strategic Leader with the proven ability to develop and execute strategies for therapeutic portfolio development. Program Manager with a history of building and leading strong cross-functional teams involving Research & Development. Effective Communicator, successful at negotiating with and managing contract researchers and manufacturers, and collaborators. Suhaib Siddiqi’s Specialties: Drug Research and Development, Nucleoside and Nucleotides for Genomics, Biologics Process Development, Technology Transfer.

Work History

Work History
Dec 2005 - May 2010

Director of Chemistry

Helicos BioSciences
• After joining Helicos BioSciences, I was responsible for creating, building and guiding the chemistry department. As a buildup process to start chemistry research department; designed and standardized recruiting program in order to motivate and train Scientists and promote teamwork. • Establish Organic Chemistry department, from scratch, with state-of-the-art Synthetic and Quality Control instrumentation. • Provide scientific leadership and management of the Organic Chemistry Department which works as part of larger multi-disciplinary Project teams. Functions include coordination of efforts with other departments to meet Project objectives and timelines. • Manage internal synthesis projects as well as synthesis projects contracted to external parties. • Institute sound project management practices (e.g. sets priorities for resources to meet project timelines)
Mar 2001 - Nov 2005

Director of Medicinal Chemistry

HK Pharmaceuticals Inc, San Diego ( Acquired by Caprotech GmbH)
• As member of Senior Executive Management Team, I was responsible for the Chemistry Research Department and day-to-day corporate management. • After joining HK Pharmaceuticals, I was responsible for creating, building and guiding the chemistry department. As a buildup process to start chemistry research department; designed and standardized recruiting program in order to motivate and train Scientists and promote teamwork. • Small Molecules and Bioconjugates Combinatorial Libraries Projects for aggressive strategic Medicinal Chemistry to discover lead drug candidates and New Chemical Entities (NCE). • Lead several projects on small molecule drug discovery optimization from idea, through lead optimization with ADME-TOX, and on to candidate compound declarations suitable for entry of compounds into the preclinical and development pipelines. • Defined and implemented departmental and corporate research objectives for therapeutic project areas in conjunction with Biology and Bioinformatics Department. • Developed and implemented aggressive strategic plan(s) and maximized available resources in order to obtain desired goals. Apply desired communication and presentation skills to promote team work and guided a group of several chemists to develop chemistry for the design, synthesis, isolation and purification of novel organic compounds for evaluation as potential drug candidates, and Capture Compounds TechnologyTM for Proteome, Functional Proteome Fractionation, Proteome Mining Technology and Proteomic Purification and Analysis. • Utilize natural products, and bioconjugates synthesis for novel compounds as drug lead candidates • Co-inventor of Patents
Oct 1995 - Mar 2001

Senior Scientist

Inspire Pharmaceuticals Inc
• Proposed establishment of Computational Chemistry Research Group as a Drug Discovery Process then Created from scratch, established and integrated as a research process the Division of Computer-Aided Drug Design, Bioinformatic and Scientific, Clinical Database Management with approximately several hundred thousand dollars per year budget. • Established new areas of scientific computing for the Biology and Chemistry Research Departments and integrated chemistry computational approaches to identify new lead drug candidates. • Successfully carried out structure based drug design, molecular modeling of G-protein coupled receptors, QSAR of ligands for G-protein coupled receptors, pharmacophore analysis and de Novo ligand design to identify novel drug candidates. • Experience in designing and synthesizing Combinatorial Libraries for aggressive strategic Medicinal Chemistry to discover lead drug candidates and New Chemical Entities (NCE). • Utilize natural products synthesis for novel compounds as drug lead candidates • Managed, designed and supervised development and installation of a corporate chemical and biological information system. • Developed Molecular modeling software WHAT IF for Windows, Ribbons for Windows and GRID for Windows. Please see http://www.cmbi.kun.nl/whatif/ • Designed and synthesized potent novel agonists and antagonists for G-protein coupled receptors to target chronic pulmonary diseases (COPDS). • Several Patent applications, for treating Chronic Pulmonary diseases had been filed with US Patent Office, and/or under preparation. • Negotiated and managed contractual arrangements with hardware and software vendors for Information Technology, Chemistry, Biology and Clinical Departments. • Participated in management, making outside contacts (at national and international level) to acquire proprietary materials and promote interests of Inspire Pharmaceuticals. • Co-inventor of Patents
Aug 1993 - Aug 1995

Research Fellow

National Institutes of Health
Designed and synthesized agonists and antagonists (ligands) for G-Protein Coupled Receptors, adenosine (A1, A2, and A3) and P2 receptors as therapeutic agents for central nervous system, cardiac and kidney diseases. This research project identified potent and selective agonists and antagonists for P2U and A3 receptors, for which ligands were unknown. Extensively utilized molecular modeling techniques to design potent ligands for adenosine receptors. Utilize natural products synthesis for novel, patentable compounds as drug lead candidates Co-inventor of Patents

Education

Education
1981 - Present

M.Sc.

AMU
1984 - 1987

Dr. tech. wiss. (Ph.D.)

Technische Universitaet Wien
1980 - 1982

M.Sc.

Trent University

Skills

Skills

Summary

Dynamic Biotech/Pharmaceuticals Executive with a track record in biotech, genome and drug discovery and development with experience in rapidly advancing biologics from research through clinical and commercial stages. Strategic Leader with the proven ability to develop and execute strategies for therapeutic portfolio development. Program Manager with a history of building and leading strong cross-functional teams involving Research & Development. Effective Communicator, successful at negotiating with and managing contract researchers and manufacturers, and collaborators. Suhaib Siddiqi’s Specialties: Drug Research and Development, Nucleoside and Nucleotides for Genomics, Biologics Process Development, Technology Transfer. Specialties Extensive research experience in most branches of Medicinal chemistry, bioorganic transformations, and Proteome. Drug Research and Development, Platform Technologies for Genome, Informatics & Scientific Software, Target Identification & Validation, R&D Alliance Management, Nucleoside and Nucleotides for Genomics and Infectious Diseases, Biologics Process Development, Technology Transfer.

References

References

Marc Levine

Suhaib is a highly talented organic chemist and manager. He built and led the organic chemistry group at Helicos BioSciences. During the two years that he worked for me, he provided both leadership to his group and was the source of many innovative ideas that led to the synthesis of novel nucleotide analogs used in single molecule DNA sequencing. Suhaib would be an asset to any organization.

Steve Lombardi

“Suhaib is an experienced manager and scientist who led the organic chemistry group at Helicos. He and his group were prolific in building a portfolio of molecules for our single-molecule team to screen and optimize.”

John Thompson

“I have worked with Suhaib for over 2 years in various capacities and enjoyed that experience. He is an excellent organic chemist with a tremendous knowledge of nucleotide and dye chemistry. He has very innovative ideas with respect to making molecules with biologically and chemically interesting properties. Suhaib has a great understanding of what will and will not work in a synthesis design and thus able to direct resources along the most fruitful path. He has been a critical member leading the team that has successfully met the very challenging requirements for single molecule DNA sequencing.”

Stan Letovsky

“Subhaib provided leadership in the very complex task of designing sets of reversible dye terminator nucleotide analogs for single-molecule sequencing at Helicos. His expertise in organic synthesis was a crucial asset for this project.”

Bill Efcavitch

Suhaib is an extremely competant and innovative organic chemistry manager and scientist. His management of the organic synthesis group led to many novel compounds, some of which were successfully commercialized by our company. I enjoyed working with him and would do so again in the future.”

Stan Lapidus

“We hired Suhaib in 2005 as Director of Chemistry. His role was to build and lead a six-person team charged with developing and manufacturing novel nucleotides for single molecule sequencing. Suhaib is a very effective professional, colleague and leader. He has my highest recommendation.”