Leiden university (LU), Netherlands
Faculty of Science
Optimization of the flowcell of a commercial benchtop calorimeter instrument. This industry joined project targets the improvement of the performance of the reagents mixing inside the flowcell of the calorimeter, also the enhancement of the heat transfer to the thermopile array, as well as the overall optimization of the sensitivity of the calorimeter, in order to improve the accuracy of the measurements of the thermochemical heat produced by enzymatic catalysed reactions inside the flowcell. This project involves complete redesign of the mixing flowcell as well as devises a new methodology for the calibration of the thermopile array.
Techniques: heat measurements, flowcell calorimetry, microfabrication, cleanroom, contact photolithography, micromilling, plastics bonding, contact angle measurements, atomic force microscopy, syringe pumping.