Andrew Bauman


I am a protein scientist and mass spectrometrist with proven success in conducting research to achieve organizational objectives in team-oriented, multi-disciplinary environments.  My primary skill is leveraging my array of experience, education, and expertise to maintain highly productive environments aligned with company goals. 

 I hold a Ph.D. in Molecular Toxicology with emphasis in Chemistry and Biochemistry and have 15 years of research experience between academia and industry.  My technical areas of expertise include proteomics, mass spectrometry, and protein and antibody production.  I have broad protein and antibody characterization experience and have conducted and managed research at a biotechnology company, the Stanford National Accelerator Laboratory, and 2 hospital research organizations.   My experience also includes team leadership, laboratory and project management, writing SOPs, conducting and overseeing QC, working with internal and external collaborators, grant/manuscript writing, training and mentoring.


  • Personnel Management and Team Leadership (6 years)
  • Mass Spectrometry-based Proteomics  (LCMS, 6 Years)
  • Protein/Antibody production/purification/characterization (12 years)
  • Spectroscopy (14 years, EXAFS, NMR, Fluorescence, UV-Vis, EPR)
  • Analytical and Preparative Chromatography (14 years, HPLC, FPLC, UPLC)
  • Process Development (5 years)
  • Enzyme Structure and Kinetics (4 years)
  • Grant, Manuscript, and Report Writing (8 Years)
  • Differential Proteomics and Biomarker Discovery (4 years)
  • Target Discovery (1 year)

Selected Publications

Bauman, AT; Broers, BA; Kline, CD; Blackburn, NJ.  A Copper-Methionine Interaction Controls the pH-Dependent Activation of Peptidylglycine Monooxygenase.  Biochemistry. (2011), 50(50), 10819-28.

Higdon, R; Hather, G; Haynes, W; Kolker, N; Bauman, AT; Picotti, P; Schmidt, A; van Belle, G; Aebersold, R; Kolker, N; IPM:  An Integrated Protein Model for False Discovery Rate Estimation and Identification in High-Throughput Proteomics. J Proteomics. (2011), 75(1), 116-121.

Kolker, E; Higdon, R; Welch, D; Bauman, A; Stewart, E; Haynes, W; Broomall, W; Kolker, N. SPRE: Systematic Protein Investigative Research Environment. J Proteomics. (2011), 75(1), 122-6.

Wolf, F; Hobby, R; Lowry, S; Bauman, A; Franza, BR; Lin, B; Rapson, S; Stewart, E; Kolker, E. Education and Data-Intensive Sciences in the Beginning of the 21st Century.  OMICS. (2011), 15(4), 217-9.

Bauman, Andrew; Higdon, Roger, Rapson, Sean; Louie, Brenton, et al. Design and Initial Characterization of the SC-200 Proteomics Standard Mixture. Omics. (2011) 15(1-2), 73-82.


Hather, G; Higdon, R; Bauman, A; von Haller, PD;  Kolker, E.  Estimating False Discovery Rates for Peptide and Protein Identification Using Randomized Databases.  Proteomics. (2010), 10(12), 2369-76.

Paddock, MN; Bauman, AT; Higdon, R; Kolker, E; Takeda, S; Scharenberg AM. Competition Between PARP-1 and Ku70 Control the Decision Between High-Fidelity and Mutagenic DNA Repair.  DNA Repair. (2011), 10(3), 338–43.

Bauman, Andrew, T.; Blackburn, Ninian, J.; Ralle, Martina.  Large Scale Production of the Copper Enzyme Peptidylglycine Monooxygenase Using an Automated Bioreactor.  Protein Expr. Purif. (2007), 51(1), 34-8.

Bauman, Andrew, T.; Jaron, Shula; Yukl, Eric, T.; Burchfiel, Joel, R.; Blackburn, Ninian, J.  pH Dependence of Peptidylglycine Monooxygenase.  Mechanistic Implications of Cu-Methionine Binding Dynamics.  Biochemistry. (2006), 45(37), 11140-50.

Bauman, Andrew, T.; Yukl, Erik, T.; Alkevich, Katsiaryna; McCormack, Ashley; Blackburn, Ninian, J.  The Hydrogen Peroxide Reactivity of Peptidylglycine Monooxygenase Supports a Cu(II)-Superoxo Catalytic Intermediate. J. Biol. Chem. (2006), 281(7), 4190-8.

Hooven, LA; Vorachek, WR; Bauman, AB; Butler, JA; Ream, LW; Whanger, PD.  Deletion Analysis of the Rodent Selenoprotein W Promoter.  J. Inorg. Biochem. (2005), 99(10), 2007-12.

Bauman, Andrew T.; Anderson, Sonia A.; Barofsky, Douglas, F.; Barofsky, Elizabeth; Malencik, Dean A.; Whanger, Phil, D.  Production and Purification of Rat Mutant Selenoprotein W With and Without Bound Glutathione.  Biochem Biophys Res Commun. (2004), 313(2), 308-13. 

Dorsch, John A.; Cook, Allen; Young, Kevin A.; Anderson, Joseph M.; Bauman, Andrew T.; Volkmann, Carla J.; Murthy, Pushpalatha P. N.; Raboy, Victor.  Seed Phosphorus and Inositol Phosphate Phenotype of Barley Low Phytic Acid Genotypes.  Phytochemistry (2003), 62(5), 691-706.   Volkmann, Carla J.; Chateauneuf, Ginger M.; Pradhan, Jyotsna; Bauman, Andrew T.; Brown, Richard E.; Murthy, Pushpalatha P. N.  Conformational Flexibility of Inositol Phosphates: Influence of Structural characteristics.    Tetrahedron Letters (2002), 43(27), 4853-4856.   Raboy, Victor; Gerbasi, Paola F.; Young, Kevin A.; Stoneberg, Sierra D.; Pickett, Suewiya G.; Bauman, Andrew T.; Murthy, Pushpalatha P. N.; Sheridan, William F.; Ertl, David S.  Origin and Seed Phenotype of Maize Low phytic Acid 1-1 and Low Phytic Acid 2-1.  Plant Physiology (2000), 124(1), 355-368.

Bauman, Andrew T.; Chateauneuf, Ginger M.; Boyd, Brian R.; Brown, Richard E.; Murthy, Pushpalatha P. N. Conformational Inversion Processes in Phytic Acid: NMR Spectroscopic and Molecular Modeling Studies.   Tetrahedron Letters (1999), 40(24), 4489-4492. 

Work History

Work History
Feb 2011 - Present

Senior Scientist and Manager of the Protein Sciences Group

VLST Corporation
  • Managed the protein sciences division (3 reports) in support of the target discovery and pre-clinical divisions, overseeing monoclonal antibody and protein production/purification, technology and process development, as well as quality control. 
  • Provided mass spectrometry expertise for trouble-shooting and technology/process development related to VLST’s mass spectrometry-based drug target discovery pipeline.
  • Played a supporting role in a PKPD study conducted with a CRO by providing reagents, creating certificates of analysis, quality control, and safety.  I also served as Principal Investigator for a related drug stability study.
  • Presented Target Discovery Packages to collaborators in the pharmaceutical industry to inform their decisions regarding potential drug target programs for possible incorporation into their own drug development pipelines.
  • Provided collaborators and CROs with protein reagents, technical reports, program updates, certificates of analysis, and technical expertise in support of drug target programs. 
Mar 2008 - Feb 2011

Research Scientist IV

Seattle Children's Research Institute
  • Performed experimental proteomics for the High-Throughput Analysis Core (HAC) and the Kolker lab.
  • Processed and analyzed complex biological samples (CSF, blood, model organisms, viruses) via LCMS.
  • Designed experiments with medical staff to investigate the underlying causes of pediatric brain and cardiac disease.
  • Analyzed the H. Influenza proteome in support of vaccine development. 
  • Developed a novel 200 known protein standard (world's largest) for process control and method development/validation.
  • Developed and implemented a protein quality control and formulation pipeline.
  • Coordinated HAC computational, statistical, and experimental staff to deliver sample reports to collaborators.
  • Optimized LCMS and wet-bench protocols to increase throughput by 50%.
  • Played a major role in establishing the HAC business plan and fee structure and in securing equipment funds.
  • Drove the development of SPIRE ( an NSF funded web-based proteomics analysis environment.
Feb 2004 - Feb 2008

Senior Research Associate

Oregon Health & Science University

  • Implemented a protein purification pipeline supporting kinetic and structural studies of peptidyl hydroxylating monooxygenase (PHM) a copper-containing mono-oxygenase and drug target.
  • Investigated mechanistic aspects of PHM by comparing structural data (EXAFS) obtained at the Stanford Synchotron Radiation Laboratory to kinetic data obtained via oxygen consumption, EPR, stopped-flow, and fluorescence spectroscopy. 
  • Developed successful protocols for maintaining the solubility and activity of PHM during reconstitution with copper, reduction of the reconstituted form, pH titrations, concentration, storage, and shipping. 
  • Maintained an Acusyst Minimax benchtop mammalian bioreactor under sterile conditions for 3 years.
  • Managed a lab team performing protein structural studies at SSRL with samples from OHSU and external collaborators. 
  • Supervised and trained staff and students on instrumentation and techniques used to conduct metalloprotein research.
  • Increased the purity, activity, and yield of PHM 2-fold by developing a novel polishing purification procedure which enabled the production of optically pure protein targets, leading to new mechanistic and kinetic discoveries.
Jan 1999 - Feb 2004

NIEHS Predoctoral Trainee

Oregon State University

  • Performed research experiments to develop leads to the function of Selenoprotein W (SeW), leading to the discovery of protein-protein interactions related to calcium-regulated phosphorylation cascades.
  • Implemented successful strategies to reduce target protein aggregation and enable recovery from inclusion bodies.
  • Produced and purified antibodies to SeW for use in affinity purification and western blotting.
  • Designed and purified peptides used to probe protein interactions and phosphorylation of SeW.
  • Produced and purified calmodulin, parvalbumin, and troponin on a gram scale for research use and commercial sale.


1998 - 2004


Oregon State University
1994 - 1998


Michigan Technological University