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At a Glance

I am passionate about using scientific evidence to improve health outcomes and healthcare delivery. I have more than fifteen years experience in health technology assessment, health outcomes research, and  preclinical laboratory research encompassing the areas of virology, gene therapy, and cancer medicine. I am well-versed in a wide range of health technologies including drugs, medical devices, surgical procedures, medical tests (including genetic testing).

Specialties: Health Technology Assessment, Comparative Effectiveness Reviews, study design, critical appraisal methodology (GRADE), health outcomes research, molecular medicine, product Innovation, team and program management

Experience

Feb 2016Present

Director of Research, Innovation, and Quality

Hayes Inc.
  • Managing the Stage Gate innovation process to develop evidence products and services
  • Providing  methodological and scientific  direction for horizon scanning and genetic test evaluation programs
  • Implementing and managing the Hayes Quality Assurance Program
Apr 2015Jan 2015

Director of Research and Innovation

Hayes Inc.
  • Implementing and managing the Stage Gate innovation process to develop evidence products and services
  • Providing  methodological and scientific  direction for horizon scanning and genetic test evaluation programs
Nov 2013Mar 2015

Managing Editor

Hayes Inc
  • Managed a team of senior research analysts
  • Accountable for scientific content and quality of 60 health technology assessments per year
  • Created and implemented product enhancements
  • Developed methodology for patient safety practices assessments
  • Provided change management during executive leadership transition
Mar 2003Oct 2013

Senior Research  Analyst/Scientific Content Editor

Hayes Inc.

Health Technology Assessment

  • Provided evidence-based recommendations regarding the efficacy and safety of new health technologies
  • Improved and validated company-internal scientific evidence grading tools
  • Provided scientific leadership for projects involving government organizations

Decision analysis

  •  Developed decision trees to guide clinical decision making

Editorial management

  • Reviewed health technology assessments of research analysts for complete and correct scientific content and evidence grading
  • Managed custom work and production workflow

Business development

  • Prepared proposals and budgets for custom projects
  • Established international business relationships
  • Interfaced with clients
Jan 2000Feb 2003

Instructor

Johns Hopkins University
  • Managed research laboratory
  • Wrote grant proposals
  • Advised students and research fellows
Sep 1997Dec 1999

Postdoctoral Fellow

Johns Hopkins University

Managerial

  • Directed students and research fellows
  • Managed and ordered supplies

Scientific

  • Independently designed research protocols and analyzed data
  • Developed plasmid constructs expressing growth factors to promote wound healing
  • Developed appropriate immunoassays to measure growth factor levels in serum and in cell culture
  • Developed measures of wound healing including digital wound tracing methodology
  • Maintained cell cultures of esophageal cancer cell lines
Jul 1995Aug 1997

Postdoctoral Fellow

Food and Drug Administration
  • Independently designed experiments to develop and test plasmid constructs for gene therapy for genital herpes simplex virus infection
  • Developed three plasmid constructs for herpes simplex virus gene therapy
  • Developed appropriate immune assays to detect and measure viral proteins in serum
  • Maintained cell cultures and virus stock
  • Presented research results at conferences
Jul 1989Jun 1990

Intern

Bayer AG
  • Independently developed a staining method for pathogenic wheat fungi to diagnose and predict disease development in the field
  • Interfaced with collaborators to design and manage field studies

Education

April 20132017(expected)

Masters of Public Policy and Management

University of York

Theory and methods in public management and public policy

Sep 1990Jun 1995

PhD

University of Illinois at Urbana-Champaign

Electron microscopic in situ localization studies of Barley Yellow Dwarf Virus protein and RNA

Sep 1987May 1989

Postgraduate Education

Nanjing University

Chinese language and culture

Oct 1981May 1987

MSc

University of Konstanz

Biology

Skills

Management

Team and project management

Outcomes Research
Health Technology Assessment

Systematic literature search

Rating the quality of individual studies

Grading the quality of the body of evidence

GRADE methodology

Bioinformatics

Comparative genomics, phylogenetics, next generation sequencing, metagenomics

Molecular Medicine

Gene therapy, targeted drugs, genetic test evaluation, pathway analysis

Software

Microsoft Office Suite: Word, Powerpoint, Excel

Webconferencing software: GoToMeeting

Reference management software: EndNote, Reference Manager

Adobe family including Acrobat and Photoshop

Decision analysis software: TreeAge

Distiller

Laboratory experience

Microbiology including all aspects of maintenance and propagation of bacteria, fungi and viruses

Cell culture including all aspects of cell culture maintenance

Protein biochemistry including all common types of protein purification/immunological assays including enzyme-linked immunoadsorbent assay, gel electrophoresis, radioimmunoassay

Light microscopy including fluorescent methods and potentiometric dyes

Electron microscopy including in situ hybridisation and immunoproteinlocalization

Gene therapy including DNA cloning and sequencing, plasmid and virus purification and construction

Continuing Education

Oct 2015Present

Genomic Data Science Certificate

Johns Hopkins University (Verified Coursera Specialization)

Concepts and tools to understand, analyze, and interpret data from next generation sequencing experiments.
Module 1: Introduction to Genomic Technologies (completed with  distinction)
Module 2: Genomic Data Science with Galaxy (completed)
Module 3: Python for Genomic Data Science (completed with distinction)

Dec 2015Jan 2016

Executive Data Science

Johns Hopkins University (Verified Coursera Certificate)

Assembling and leading a data science enterprise.

Module 1: A Crash Course in Data Science

Module 2: Building a Data Science Team

Module 3: Managing Data Analysis

Module 4: Data Science in Real Life

Sep 2015Oct 2015

Bioinformatics Methods I Certificate

University of Toronto (Verified Coursera Certificate)

Topics covered in this course: comparative genomics, multiple sequence alignments, phylogenetics, selection analysis, next generation sequencing, metagenomics.

Apr 2013Mar 2014

University Certificate in Public Policy and Management

University of York

Theory and methods in public management and public policy

Oct 2011May 2013

University Certificate in Cross-Cultural Training, Engagement, and Management

Heidelberg University of Education

The course included modules on methods for cultural sensitivity training, moderating diverse groups, and cross-cultural project management and consulting.

Mar 2011Jun 2011

Project Leadership Certificate

eCornell University, Ithaca, New York, USA

The course included modules on project management methods, managing diversity, earned value management, influence without authority, and conflict resolution.

Dec 2010Jan 2011

Regulatory Affairs Certificate: Pharmaceuticals

RAPS, Maryland, USA

The course included modules on ethics, global regulatory strategy, pharmaceutical definition & lifecycle, regulation of pharmaceuticals and combined products, project management, effecitve communication & negotiation,  and medical writing.

MOOCS

Social Network Analysis - University of Michigan via Coursera

Introduction to Pharmacoeconomics - ISPOR Distance Learning Program

Scientific Publications

Mendgen K., Nass P.H. (1988). The activity of powdery-mildew haustoria after feeding the host cells with different sugars, as measured with a potentiometric cyanine dye. Planta 174(2), 283-288.
Mauler-Machnik A., Nass P. (1990). Einfache Methode zur Frühdiagnose von Pseudocercosporella herpotrichoides mit dem Bayer Getreide-Diagnose-System nach Verreet/Hoffmann. Gesunde Pflanze 42, 130-132.
Nass, P.H., Jakstys B.P., D'Arcy C.J. (1995). In situ localization of barley yellow dwarf virus in oats. Phytopathology 85, 556-560.
Nass, P. H., Domier, L. L., Jakstys, B. P., and D'Arcy, C. J. (1998). In Situ Localization of Barley Yellow Dwarf Virus-PAV 17-kDa Protein and Nucleic Acids in Oats. Phytopathology 88(10), 1031-1039.
Nass, P. H., Elkins, K. L., and Weir, J. P. (1998). Antibody response and protective capacity of plasmid vaccines expressing three different herpes simplex virus glycoproteins. J Infect Dis 178(3), 611-7.
Tchorzewski, M. T., Duncan, M. D., Nass, P., Qureshi, F. G., Gearhart, P. J., Winchurch, R., and Harmon, J. W. (1998). Characterization of an aFGF gene expression vector with therapeutic potential. J Surg Res 77(2), 99-103.
Byrnes, C. K., Khan, F. H., Nass, P. H., Hatoum, C., Duncan, M. D., and Harmon, J. W. (2001). Success and limitations of a naked plasmid transfection protocol for keratinocyte growth factor-1 to enhance cutaneous wound healing. Wound Repair Regen 9(5), 341-6.
Nass, P. H., Elkins, K. L., and Weir, J. P. (2001). Protective immunity against herpes simplex virus generated by DNA vaccination compared to natural infection. Vaccine 19(11-12), 1538-46.
Tihan, T., Harmon, J. W., Wan, X., Younes, Z., Nass, P., Duncan, K. L., and Duncan, M. D. (2001). Evidence of androgen receptor expression in squamous and adenocarcinoma of the esophagus. Anticancer Res 21(4B), 3107-14.
Wan, X., Duncan, M. D., Nass, P., and Harmon, J. W. (2001). Synthetic retinoid CD437 induces apoptosis of esophageal squamous HET-1A cells through the caspase-3-dependent pathway. Anticancer Res 21(4A), 2657-63.
Wan, X., Nass, P., Duncan, M. D., and Harmon, J. W. (2001). Acidic fibroblast growth factor overexpression partially protects 3T3 fibroblasts from apoptosis induced by synthetic retinoid CD437. J Mol Med 79(2-3), 143-8.
Byrnes, C. K., Nass, P. H., Duncan, M. D., and Harmon, J. W. (2002). A nuclear targeting peptide, M9, improves transfection efficiency in fibroblasts. J Surg Res 108(1), 85-90.
Byrnes, C. K., Nass, P. H., Shim, J., Duncan, M. D., Lacy, B., and Harmon, J. W. (2002). Novel nuclear shuttle peptide to increase transfection efficiency in esophageal mucosal cells. J Gastrointest Surg 6(1), 37-42.
Byrnes, C. K., Bahadursingh, A., Akhter, N., Parinandi, N. L., Natarajan, V., Montgomery, E., Tihan, T., Duncan, M. D., Nass, P. H., and Harmon, J. W. (2003). Duodenal reflux produces hyperproliferative epithelial esophagitis-a possible precursor to esophageal adenocarcinoma in the rat. J Gastrointest Surg 7(2), 172-80.
Byrnes, C. K., Malone, R. W., Akhter, N., Nass, P. H., Wetterwald, A., Cecchini, M. G., Duncan, M. D., and Harmon, J. W. (2004). Electroporation enhances transfection efficiency in murine cutaneous wounds. Wound Repair Regen 12(4), 397-403.
Levine S., Nass P., Rogstad T. Effectiveness Guidance Document. Devices for Local Treatment of Chronic Wounds. Baltimore, MD: Center for Medical Technology Policy; 2009.
Nass P., Levine S., Yancy C. (2012). Methods for involving patients in topic generation for patient-centered comparative effectiveness research - an international perspective. Patient-Centered Outcomes Research Institute (PCORI). Available at: http://www.pcori.org/what-we-do/methodology/
Nass P. (2012). Photovoice: The Use of Photography in Participatory Healthcare Research and Integrated Care. Gaceta Sanitaria. 26:275.

Webinars

Hayes Inc. Webinar Series

Basic Concepts in Nanomedicine (May 28, 2009; September 28, 2009)

Press Coverage

Jacksonville Business Journal (Issue 25.-31. August, 2006)