• Hyderabad Telangana, India
  • +91-7095624914
  • parammakam@gmail.com, parameshwar.makam@mylan.in

Dr. Makam Parameshwar, Ph.D.

Research Executive, Chemical R&D Center, Mylan Laboratories Limited.

Summary

9 years of Research experience: 4 years in reputed pharmaceutical companies like Mylan Laboratories Limited, Matrix Laboratories Limited (A subsidiary of Mylan Inc. U.S.A.)  and Dr. Reddy’s Research Foundation (Discovery & Research), Dr. Reddy’s Laboratories Limited and 5 years of research on Ph. D thesis titled “2-Aminothiazole Derivatives as Antituberculosis and Antimalarial Agents: Design, Synthesis, in silico and in vitro Studies”. I have three research articles and two patents and several best oral and poster presentation awards to my credit. Knowledge on executing the synthesis of target molecule from R&D to commercialization by considering from literature search to IPR. 

Work History

Work History

Research Executive

2015 - Present
Chemical R & D, Mylan Laboratories Limited, Hyderabad

Project A: Treprostinil: Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension. Studies are being carried out towards the stereo selective synthesis of Treprostinil and its diethanolamime salt and their polymorph studies.

Project B: (5S)-Dec-1-yn-5-ol: Key intermediate for the preparation Treprostinil.

Project C: Atropine sulfate monohydrate: Class of Tropane alkaloids used as preanesthetic medication, Mydriatic, antispasmodic Anticholinergic, Muscarinic antagonist.

Ph.D. Research Work 

Jun 2009 - May 2014
University of Delhi &  Pondicherry University

Ph. D thesis titled “2-Aminothiazole Derivatives as Antituberculosis and Antimalarial Agents: Design, Synthesis, in silico and in vitro Studies” under the supervision of Dr. K. Tharanikkarasu, Professor and Head, Department of Chemistry, University of Delhi and Pondicherry University.

Publications: 

1. Parameshwar Makam, Ramakrishna Kankanala, Amresh Prakash, Tharanikkarasu Kannan, 2-(2-Hydrazinyl)thiazole derivatives: Design, synthesis and in vitro antimycobacterial studies, European Journal of Medicinal Chemistry, 69 (2013) 564-576.
2. Parameshwar Makam, Prasoon Kumar Thakur, Tharanikkar asu Kannan, 2-(2-Hydrazinyl)thiazoles as antimalarial agents: in vitro and in silico analyses, European Journal of Pharmaceu tical Sciences, 52 (2014) 138–145.
3. Parameshwar Makam, Tharanikkarasu Kannan, 2-Amino thiazole derivatives as antimycobacterialagents: Synthesis, characterization, in vitro and in silico studies, European Journal of Medicinal Chemistry, 87 (2014) 643-656.
4. Parameshwar Makam, Tharanikkarasu Kannan, Design, synthesis, single crystal studies of thiazole derivatives and their antimicrobial, antifungal and cytotoxicity evaluation (Manuscript underpreparation).

Senior Chemist

Jan 2008 - Jan 2009
Chemical R & D, Matrix Laboratories Limited, Hyderabad (A subsidiary of Mylan Inc. U.S.A.)

Project A: Dexlansoprazole: Developed new synthetic methodology towards the total stereo selective synthesis of Dexlansoprazole (R-Isomer of Lansoprazole), an antiulcer drug.

Project B: Darifenacin Hydrobromide: Treatment of Overactive bladder with symptoms of Urinary incontinence, urgency and frequency treatment drug.

Patents: 

1. Saswata Lahiri, Lakshmana Rao Vadali, Swamy Saidugari, Verra Narayana Bandlamudi, Parameshwar Makam, Seshadri Rao Manukonda, Debashish Datta “Novel compounds for pro- ducing substituted sulfoxides, process for producing the same and use there of”, WO/2010/035283.
2. Saswata Lahiri, Lakshmana Rao Vadali, Swamy Saidugari, Verra Narayana Bandlamudi, Parameshwar Makam, Seshadri Rao Manukonda, Debashish Datta “Compounds for producing substituted sulfoxides, process for producing the same and use there of”, US 20110184182.

Research Trainee

Jul 2007 - Jun 2008
Chemical R&D, Matrix Laboratories Limited

Project A: (S)-Pregabalin: Analgesic, anti convulsant and anxio-lytic drug.
Project B: Paroxetine Hydrochloride: Anti-depressant and anti-Parkinson agent. Extensively studied and developed new method for the synthesis of anhydrous and hemi-hydrate forms.

Education

Education

PG Diploma in Intellectual Property Rights

2015 - 2016
IGNOU

Pursuing

Doctor of Philosophy (Ph.D)

2009 - 2014
Pondicherry University

Ph. D thesis titled “2-Aminothiazole Derivatives as Antitubercu losis and Antimalarial Agents: Design, Synthesis, in silico and in vitro Studies” under the supervision of Dr. K. Tharanikkarasu, Professor and Head, Department of Chemistry, University of Delhi & Pondicherry University.

Master of Science (M. Sc.) – Chemistry

2005 - 2007
Jawaharlal Nehru Technological University

Dissertation: “Studies towards the Total Synthesis Of 4-Biaryl-1-Phenyl-Azetidine-2-One Derivatives as Cholesterol  Absorp tion Inhibitors” under the supervision of Dr. Sanjita Sasmal, Dr. Reddy’s Research Foundation, (Discovery & Research), Hyderabad. Passed with 75.8%, Distinction.

Bachelor of Science (B.Sc.)

2001 - 2004
Nizam College, Osmania University

Subjects: Zoology, Chemistry, Computer Applications, English and Sanskrit. Passed with  70%, 1st Division. 

Secondary School (X) & Senior School (XII)

1998 - 2001
Jawahar Navodaya Vidyalaya, Mahabub Nagar.

Subjects: Mathematics, Science, Social Science, English and Telugu. Passed with  64.2%, 1st Division. Subjects: Biology, Chemistry, Physics, English and Hindi. Passed with 62.4%, 1st Division. 

Skills

Skills

Work Nature

Ability to perform both as a group/team member, individual and able to lead  • Adaptability to the changing technologies by implementing my success cycle of observing, learning, practicing and performing at every moment. 

Computer knowledge

 MS-Office and Familiar scientific softwares: SciFinder scholar, single crystal solving softwares (Olex, WingX, Mercury, Ortep etc.), NMR (Mnova, Bruker & Zeol), Protein – Ligand interaction studies by Autodock, Cygwin, Chem draw, Origin, Endnote, Minitab software etc.

Communication

Trained in manuscript and grant writing

 Effective written and verbal communications in English, Hindi and Telugu

Research 

• Literature search, devise synthesis and transformation for the most common functional groups, identify and analyze possible synthetic routes towards a specific target molecule • Plan and designing equipment for various types of laboratory experiments • Handling sensitive reactions: Moisture, oxygen, temperature and pressure • Optimization of reaction conditions to maximize the yield and purity of the target molecule from milligram to kilo gram scale • Stereo, regio selective synthesis and their analysis • Extraction, work-up, crystallization, recrystallization, distillation, drying and purification of solvents • Chromatographic methods (TLC, Column, Flash Column, HPLC, G.C). • Structure determination by spectroscopic methods (Mass, IR, NMR (H1 , C13), UV, XRD) • Laboratory notebooks, writing a report and GLP • Understanding on subjects such as Safety in the laboratory, disposal and destruction of dangerous materials, waste disposal. 

Research guidance:

Worked as laboratory research assistant for Integrated M.Sc. chemistry laboratory for a semester  Trained eight M.Sc. and two M. Tech. students of organic chemistry towards their research and dissertation submission and also received a lot of applause from the students

Grants/ Fellowships/ Awards:

1. Weavers’ Welfare Trust meritorious Fellowship June, 2005 to April 2009 (two academic years). 

2. Senior Research Fellow, CSIR, New Delhi 10th June, 2009 to 30th November, 2012. 
3. Pondicherry University Ph. D. fellowship 1st Dec, 2012 to 30th April, 2014. 
4. Three best oral presentation awards, three best poster awards at various national level conferences.
5. Secured University third position on merit in M. Sc. programme (2007).
6. Awarded first prize in essay writing-cum-presentation competition on topic “Theory of aromaticity” conducted by Royal Society of Chemistry (London), Deccan Section, India (2006).
7. Awarded third prize in essay writing-cum-presentation competition on topic “Medicinal plants and their Applica tions” conducted by Royal Society of Chemistry (London), Deccan Section, India (2005).
8. First rank holder in national level M. Sc. - Chemistry entrance examination conducted by J.N.T.University (2005).
Secured third position on merit in B. Sc. programme (Z. C. CA), (2004).
9. Double promoted from the position of Research Trainee to Senior Chemist at Matrix Laboratories Ltd.

Scientific Conferences/seminars/workshops

1. Presented a poster at two –day seminar cum workshop on “Role of Modern Instrumental Techniques in Drug Discovery & Development”, jointly organized by Royal Society of Chemistry (London) – India Deccan Local Section (RSC-IDLS) & Raghavendra Institute of Pharmaceutical Education & Research (RIPER) at Anatapuramu on 10th & 11th October 2015 titled “A search of 2-Aminothiazole as Plausible Scaffold against Mycobacterium Tuberculosis and Plasmodium Falciparum”, Makam Parameshwar and Tharanikkarasu Kannan. Awarded with best poster presentation.
2. Delivered oral talk at Indo-French conference on, “New Trends in Chemistry and Chemical Biology with a Special Focus on CNS Disorders”. Organized by CSIR-IICT & supported by IFCPAR (CEFIPRA), held during 9th -12th November 2014 at Puducherry, India titled 2-Aminothiazole derivatives as anti-TB and anti-malarial agents, Tharanikkarasu Kannan, Parameshwar Makam.
3. Presented a poster at “Indo-French Seminar on Bio-inorganic Approaches to Current Health Problems” conducted by Department of Chemistry, Pondicherry University and Indo-French Center for Promotion of Advanced Research, 24th -28th March, 2014 titled “2-Aminothiazole Scaffold as Plausible candidate against Mycobacterium Tuberculosis and Plasmodium Falciparum” Makam Parameshwar and Tharanikkarasu Kannan.
4. Delivered oral talk at “CHEMZEAL-2014” conducted by Department of Chemistry, Pondicherry University, 18th February, 2014 titled “2-Aminothiozoles derivatives: Design, Synthesis, in vitro and in silico evaluation against Mycobacterium Tuberculosis and Plasmodium Falciparum” Makam Parameshwar and Tharanikkarasu Kannan. Awarded with best oral presentation.
5. Presented a poster at “International Conference on Chemical Biology: Disease Mechanisms and Therapeutics (ICCB- 2014)”conducted by Chemical Biology Society of India in association with CSIR-Indian Institute of Chemical Technology, Hyderabad, 6th - 8th February, 2014 titled “2-Aminothiazole derivatives: Design, synthesis and their in vitro and in silico evaluation against Mycobacterium  uberculosis and Plasmodium falciparum” Makam Parameshwar and Tharanikkarasu Kannan.
6. Delivered oral talk at “National Symposium on Recent Advances in Chemistry (NSRAC – 2013)” conducted by Department of Chemistry, Pondicherry University, 22nd & 23rd March, 2013 titled “Aminothiazoles as Antituberculosis and Antimalarial agents: Synthesis and biological studies” Makam Parameshwar and Tharanikkarasu Kannan.

7. Delivered oral talk at “National Conference on Drug Discovery and Cellular Dynamics(DDCD)-2013” conducted by Department of Biochemistry and Molecular Biology, Pondicherry University, 21st - 22nd March, 2013 titled “Design, Synthesis, Characterization and Biological evaluation of 2-(2-hydrazinyl)thiazole derivatives against infectious and neglected diseases: Tuberculosis, Malaria and Microbial infections.” Makam Parameshwar and Tharanikkarasu Kannan. Awarded with best oral presentation.

8. Presented a poster at “Symposium on science for shaping the future of India” conducted by The Indian Science Congress Association (ISCA), Puducherry, 15th – 16th March, 2013 titled “Synthesis, characterization and biological evaluation of 2-(2-Hydrazinyl)thiazole derivatives as tubercolustatic, antimalarial and anti-microbial agents.” Makam Parameshwar and Tharanikkarasu Kannan. Awarded with best poster.
9. Presented a poster at “5th International Symposium on Current Trend in Drug Discovery and Research (CTDDR-13): Drug Development for Orphan / Neglected Diseases” conducted by Central Drug Research Institute (CDRI), Lucknow, 26th - 28th February, 2013 titled “2-(2-Hydrazinyl)thiazole derivatives: Possible scaffold against neglected diseases” Makam Parameshwar and Tharanikkarasu Kannan.
10. Presented a poster at “National Conference on Frontier Areas in Chemistry (NCFAC)” conducted by Department of Chemistry, Pondicherry University, 22nd December, 2013 titled “Synthesis of poly (ethylene oxide) based ABA type amphiphilic tri-block copolymers through anionic polymerization and study of their self-assembly behavior” Makam Parameshwar, Palas Jyoti Das, Anil Barak and Tharanikkarasu Kannan. Awarded with the best poster award.
11. Selected as one among in all India research scholars selection to participate in the “8th Technology Led Entrepreneurship Program (TLEP)” conducted by HRDG, CSIR, New Delhi, 4th -18th July, 2011 and presented oral talk on a business plan. Awarded with Second best Business plan award.
12. Attended the national symposium on the topic “National Conference on Green and Sustainable Chemistry” Organized by Chemistry group, Birla Institute of Technology & Science (BITS), Pilani, 19th -21st February, 2010.
13. Attended workshop on “Information Literacy & Competency” Organized by Delhi University Library system, University of Delhi, Delhi. 14th March, 2011.
14. Attended workshop on “Information Literacy & Competency” Organized by Delhi University Library system, University of Delhi, Delhi. 23rd February, 2010.
15. Presented seminar on topic “Effects of Solvents on Organic Reactions” at Matrix Laboratories Ltd.

Sports and Extracurricular Activities  

1. Cricket team member of Matrix laboratories limited (R&D).

2. Participated in cluster level games & sports consecutively for six years from VI – XII Standard.

3. Studied IX Standard at Sri Ganga Nagar, Rajasthan as a part of National Integration Programme.

Personal Information

Parents: Makam Mallaiah & Jayalakshmi.                               Date of Birth: 10-06-1984.                                             Status: Married

References 

1. Prof. K. Tharanikkarasu Kannan, Department of Chemistry, Pondicherry University, Kalapet, Puducherry, India 605014. Mobile: +91-9894246406, tharani.che@pondiuni.edu.in

2. Prof. V. Peesapati, MSc PhD CChem FRSC, Hon. Secretary, RSC – Deccan Section Hyderabad, India (Former Professor OU, JNTU & NIPER) +91-9391014579, rscdc.vpeesapati@gmail.com

3. Dr. C. R. Ramanathan, Assistant Professor, Department of Chemistry, Pondicherry University, Puducherry – 605 014. Tel: +91-413-2654416, crrnath.che@pondiuni.edu.in 

Declaration

I hereby declare that the above mentioned information is correct up to my knowledge and I bear the responsibility for the correctness of the above mentioned particulars.

Date:                                                      Place:Hyderabad                                    (Dr. Makam Parameshwar)