Dinah Velta Parums

Dinah Velta Parums

Work History

Work History

CONSULTANT / ASSOCIATE LECTURER

NHS / University

Clinical Service Work for Papworth Hospital Trust.

The Department of Histopathology at Papworth Hospital processed 2,000 cardiac and pulmonary surgical specimens per year with approximately 500 upper GI specimens. My specialty areas of diagnostic interest included pulmonary, cardiovascular, ENT, upper GI, soft tissue and Haematopathology. I shared the clinical surgical pathology reporting, pulmonary cytology reporting, post mortem service and on-call service with two other Histopathology Consultants and had responsibility for reviewing Cardiac, Pulmonary and Vascular Pathology and Cardiothoracic Transplant Pathology in adults and children. I undertook  hospital post-mortems and post-mortems on behalf of Her Majesty’s Coroner (up to 90 per year in total). I reviewed tertiary referrals of Cardiac, Vascular, GI and Pulmonary Pathology. I continued to be involved as an independent Histopathology expert for review of Cardiovascular and Pulmonary medico-legal cases. I had a two sessional general pathology commitment at Addenbrooke’s Hospital which had a general surgical pathology workload of 24,000 surgicals per year.

Audit/Clinical Effectiveness for Papworth Hospital Trust:

I was the Lead Pathologist for upper GI pathology at Papworth and attend weekly multidisciplinary team (MDT) meetings at Addenbrooke’s Hospital. I participated in weekly MDT pulmonary oncology meetings. I co-presented a weekly Transplant Pathology meeting and present cases at the monthly Cardiothoracic Audit meetings. I participated in the Pulmonary Club slide meetings and in case reviews as part of the UK Heart Lung Transplant Pathology Group. I was Regional College Representative for the National Confidential Enquiry in to Postoperative Deaths (NCEPOD).

Postgraduate Teaching and Supervision Activities for Papworth Hospital Trust:

I taught trainees as part of theAnglia/Oxford Regional Training Scheme.

Management Activities for Papworth Hospital Trust:

I was on the Trust R&D Research Review panel. I represented the combined Radiology/Pathology Directorate at Papworth at the Trust Risk Management Group.

Continuous Medical Education (CME)/Continuous Professional Development (CPD) Activities for Papworth Hospital Trust:

I was involved in the training and appraisal of Biomedical Scientists within the Department and I continued to supervise research projects involving Biomedical Scientists.

Feb 2004 - Feb 2008

Principal Physician / Pathologist, Discovery Medicine, Oncology

Astrazeneca

Summary of the Role of Principal Physician / Pathologist

From February 2004 until January 2008, I developed a new capability (Histopathology) within Astrazeneca which supported the pre-clinical and clinical translational science Oncology biomarker programme including in-house and outsourced pharmocogenetics analysis.

Evaluation of the light microscopic appearance of human and animal tissue samples and immunohistochemistry (IHC) signals to support projects was involved. This role included the evaluation of external providers of histopathology, IHC and pharmacogenomics worldwide, resulting in a Preferred Providers list with interactions with clinical and scientific key opinion leaders (KOLs).

This lead to the development of a quality plan for outsourced project work. Other experience gained in industry has included writing patents, SOPs, training manuals and guidelines including e-learning modules for use in clinical trials.

During these four years, my specialist expertise brought the added value of being Pathology adviser on the Hepatotoxicity Advisory Panel and the new Safety Knowledge Group and review of cases and reports for Global Drug Safety and drug safety physicians.

Such high level specialist input was provided in 2004/2005 in to the ISEL study (for IRESSA) with biomarker data delivery to the FDA; this was the largest biomarker study to date undertaken in a clinical trial and this study provided the model for support for the ongoing Phase III tissue-based biomarker studies (IRESSA, ZACTIMA, RECENTIN).

KEY PUBLICATIONS:

Donovan MJ, Kotsianti A, Bayer-Zubek V, Verbel D, Teverovskiy M, Cordon-Cardo C, Costa J, Greco FA, Hainsworth JD, Parums DV. A systems pathology model for predicting overall survival in patients with refractory, advanced non-small-cell lung cancer treated with gefitinib. Eur J Cancer. 2009 May;45(8):1518-26.

http://www.ncbi.nlm.nih.gov/pubmed/19272767

Hirsch FR, Dziadziuszko R, Thatcher N, Mann H, Watkins C, Parums DV, Speake G, Holloway B, Bunn Jr PA, Franklin WA. Epidermal Growth Factor Receptor Immunohistochemistry: Comparison of Antibodies and Cut-off Points to Predict Benefit from Gefitinib in a Phase III Placebo-Controlled Study in Advanced Non-Small Cell Lung Cancer. Cancer, 2008, 112(5):1114-21.

http://www.ncbi.nlm.nih.gov/pubmed/18219661

and

http://onlinelibrary.wiley.com/doi/10.1002/cncr.23282/abstract

Hirsch FR, Varella-Garcia M, Bunn PA Jr, Franklin WA, Dziadziuszko R, Thatcher N, Chang A, Parikh P, Pereira JR, Ciuleanu T, von Pawel J, Watkins C, Flannery A, Ellison G, Donald E, Knight L, Parums D,Botwood N, Holloway B. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer. J Clin Oncol. 2006 Nov 1;24(31):5034-42.

http://www.ncbi.nlm.nih.gov/pubmed/17075123

Wookey, A, Ellison, G, Donald, E, McCormick, R, Smith, J, Parums, D, Flannery, A, Gibson, N, March, R. Genetic Heterogeneity of Tumours and implications for Epidermal Growth Factor Receptor Mutation Detection in Non Small Cell Lung Cancer Patients. Abstract and Poster 3390. AACR, April 2005.

http://www.abstractsonline.com/viewer/viewAbstract.asp?CKey={B74B45DA-99A5-4496-A2EA-8A525AD0A1C3}&MKey={218FF7E7-9F17-4030-9BB4-8C029B0C9B4E}&AKey={728BCE9C-121B-46B9-A8EE-DC51FDFC6C15}&SKey={7CE4DF10-EEC9-4132-B659-5BBF3C75C385}

Katz, S.D., Parums, D.V. Sympathetic activation by sildenafil. Circulation 2001;104:119-200.

http://www.ncbi.nlm.nih.gov/pubmed/11723034

Sep 1996 - Mar 1999

CONSULTANT / HONORARY SENIOR LECTURER IN CARDIOTHORACIC & TRANSPLANT PATHOLOGY, FREEMAN HOSPITAL

NHS / UNIVERSITY

Clinical Service Work for the Freeman Hospitals’ Trust/Newcastle upon Tyne Hospitals’ NHS Trust:

The Department of Histopathology at the Freeman Hospital processed 11,000 surgical specimens per year.  This department received general histopathology specimens including those from local General Practitioners with some specialty Cardiothoracic, Renal, Urological, Gastrointestinal and Transplant Pathology. I shared the clinical surgical pathology reporting, post mortem service and on-call service with three other Histopathology Consultants. I also developed an interest in the Pathology of the Mediastinum and continued to develop an interest in Haematopathology, and pulmonary and lymphoid pathology of immune-suppression. I undertook hospital post-mortems and post-mortems on behalf of Her Majesty’s Coroner (up to 100 per year in total). I performed post-mortems and prepared them for presentation at monthly clinical audit  meetings. I reviewed tertiary referrals and continued to be involved as an independent expert for review of medico-legal cases. I developed a particular expertise in the reporting of occupational lung disease cases, in particular mesothelioma, and in the ultrastructural analysis of cilia in nasal and bronchial brushings. I establised a new Cytopathology service on site for reporting of broncho-alveolar lavages (BAL) and sputum cytology in transplant cases and in paediatric pulmonary disease.

Audit/Clinical Effectiveness for the Freeman Hospitals’ Trust/Newcastle upon Tyne Hospitals’ NHS Trust:

I organised and presented a fortnightly Pulmonary Pathology Meeting and presented cases at the monthly Cardiothoracic Audit meetings. I participated in the Northern Regional Surgical Pathology EQA, the Pulmonary Club slide meetings and in case reviews as part of the UK Heart Lung Transplant Pathology Group. I organised the immunohistochemistry and histology laboratory request procedures at Freeman (based on the RPMS proforma) and commenced audit of the immunohistochemistry service and grading of transplant rejection in paediatric cardiac biopsies. In May 1997, I organised a clinical audit of Histopathology services at Freeman Hospital in the form of a questionnaire to all clinicians.

Postgraduate Teaching and Supervision Activities for the Freeman Hospitals’ Trust/Newcastle upon Tyne Hospitals’ NHS Trust:

I taught trainees on rotation through the Department as part of theNorthern Regional Training Scheme and as part of the Northern Region MRCPath. Teaching Programme. I participated in the MSc Course in Biomedical Sciences for the University of Newcastle.

Management Activities for the Freeman Hospitals’ Trust/Newcastle upon Tyne Hospitals’ NHS Trust:

From October 1996, with the support of the Trust Managers, I was involved in the upgrading of the Pathology Seminar Room to facilitate clinico-pathological meetings, the development of a small Molecular Pathology Laboratory on site and a small Research Immunohistochemistry Laboratory. In October 1997 I was involved in the preparations for CPA inspection of Histopathology at Freeman Hospital (full accreditation achieved). During this time, with Consultant and technical colleagues, I was involved in the process of review of the whole of Pathology for the Investor’s in People Award. From 1st April 1998, I was appointed as Head of Department of Histopathology at Freeman Hospital with 11,000 surgical biopsies per year; 3.8 wte Histopathology Consultants; 24 members of technical and clerical staff; a Departmental budget of £750,000. I was involved in activities to review and develop the Department. From 1st April 1998, Freeman Hospital began the process of a management merger with the Royal Victoria Infirmary and the City Trust (based at Newcastle General Hospital) to form the Newcastle upon Tyne Hospitals’ NHS Trust. I was involved in the process of integration of two Histopathology Departments across two sites. I was involved in setting up a Working Party for Review of Mortuary Services across the Trust.

Continuous Medical Education (CME)/Continuous Professional Development (CPD) Activities for the Freeman Hospitals’ Trust/Newcastle upon Tyne Hospitals’ NHS Trust:

I was involved in the training and appraisal of Biomedical Scientists within the Department. I have supervised MSc project work (Mrs Nicola Johnson - “The Role of Calretinin in the Diagnosis of Mesothelioma” ; Mrs Allison Carpenter - “The Role of Angiogenesis in Human Atherosclerosis”). I supervised the research work of a senior member of technical staff (MLSO 2) Mr. Richard Charlton. I supervised the training of technical staff in immunohistochemistry and non isotopic in situ hybridisation (NISH). In October 1998, I was appointed as a Deputy of the R&D Committee for the Trust. 

Oct 1993 - Sep 1996

SENIOR LECTURER & HONORARY CONSULTANT IN HISTOPATHOLOGY, ROYAL POSTGRADUATE MEDICAL SCHOOL, HAMMERSMITH HOSPITAL

UNIVERSITY / NHS

Clinical Service Work for the Hammersmith Hospitals’ Trust:

The Department of Histopathology at the Hammersmith Hospital processed 12,000 surgical specimens per year. During my three years as Senior Lecturer and Honorary Consultant I shared the Surgical Pathology reporting with four other Histopathology Senior Lecturers / Consultants. I shared the Surgical Cytopathology reporting (3,000 cases per year) jointly with two other Consultants, including fine needle aspiration (FNA) Cytology.  I shared with Professor Krausz the Gynaecological Cytopathology reporting. I undertook hospital post-mortems and post-mortems on behalf of Her Majesty’s Coroner.

Audit/Clinical Effectiveness for the Hammersmith Hospitals’ Trust:

I participated in the Gynaecological Cytology Regional EQA from 1993 to 1996. From May to December, 1995 I was Histopathology Consultant Representative at the Total Quality Management (TQM) meetings in Histopathology. I organised the immunohistochemistry laboratory request procedures.

Postgraduate Teaching and Supervision Activities for the Hammersmith Hospitals’ Trust:

I taught Surgical Pathology, Cytopathology and Post Mortem Pathology to trainees on rotation through the Department as part of theNorth West Thames Regional Training Scheme. I organised and participated in the Advanced Surgical Pathology Course, teaching the whole of the Pulmonary Pathology session. I organised and taught a one week postgraduate course, Update in Cardiovascular Pathology in September 1994. I taught the Cardiovascular modules of the MSc Course in Histopathology in 1996 and the MSc Course in Experimental Pathology and Toxicology in 1994 and 1995 and the Diploma in Clinical Pathology (Histopathology) from 1993 to 1995. I was MSc (London) project supervisor to Miss Anne Marie Larkin (1994), Miss Funmilayo Belgore (1995), Miss Michelle Ashton (1995) and Dr. F. Darabipour (1996). I was BSc (London) project supervisor to Miss Natali Chung, Charing Cross Hospital Medical School (1996). During 1995 and 1996 I organised the Part I and Part II Practical Examinations for Membership of the Royal College of Pathologists, held at Hammersmith Hospital. I taught trainees in Histopathology on the North West Thames Regional Training Scheme.

Management Activities for the Hammersmith Hospitals’ Trust:

I was involved in the preparation of the Department for Clinical Pathology Accreditation (CPA) which was awarded to the Department of Histopathology in May, 1994. I was involved in the process of Trust merger and merger of Departments between the Hammersmith Hospital and Charing Cross Hospital (Imperial College School of Medicine), during 1994 to 1996.

Sep 1990 - Aug 1993

CLINICAL TUTOR IN PATHOLOGY / HONORARY SENIOR REGISTRAR, NUFFIELD DEPARTMENT OF PATHOLOGY, OXFORD

UNIVERSITY / NHS

The post of Clinical Tutor in Pathology involved the organization of a 10 week Laboratory Medicine Course for up to 100 first year clinical medical students. This included organizing over 100 lectures with 20 practical classes, weekly tutorials and clinical sessions together with a seminar series entitled Advances in Pathology, which ran with the Course. Supervision of daily post-mortem attendance and participation by the students and post mortem video teaching sessions. I organized a final written examination using a pool of multiple choice questions and a practical examination in all pathology disciplines, assessment by production of two scientifically written case commentaries, each in pathology and a final viva voce examination which was attended by all the students and 40 examiners.

Other teaching roles:

1989 - 1993: Tutorials in Pathology (Cellular Pathology, Immunology and Microbiology) and setting of college collections, Balliol College, Wadham College and Jesus College, Oxford University (12 students per year); demonstrating practical classes, Sir William Dunn School of Pathology, Oxford University; supervising 3 undergraduate research projects for the Final Honours School in Physiological Sciences, Oxford University.

1991 - 1993: College Lecturer in Pathology, Balliol College, Oxford. This post involved giving weekly tutorials, setting of college collections, administration and interviewing for admission.

Other administrative roles:

Jan. 1993 - April 1994: Pathology representative on the Committee for the Review of the Clinical School, Board of the Faculty of Clinical Medicine, Oxford University (Chairman: Professor Sir David Weatherall).

1989 - 1993: Clinical Advisor, Oxford University Medical School.

1990 - 1993: Pathology Representative on the Curriculum and Examinations Committee, Oxford University Medical School.

1989 - 1993: College Advisor, Wolfson College, Oxford.

Awards and honours:

1991: Membership (by examination) of the Royal College of Pathologists (MRCPath).

1991:  Fellowship from the Pathological Society of Great Britain & Ireland.

1993: Association of Clinical Pathologists (ACP) Travel Fund Award to study for one month with Professor Margaret Billingham, Stanford University Medical School, U.S.A. (May 1993).

Sep 1988 - Aug 1990

CLINICAL LECTURER IN PATHOLOGY / HONORARY SENIOR REGISTRAR, NUFFIELD DEPARTMENT OF PATHOLOGY, OXFORD

UNIVERSITY / NHS

Clinical Lecturer and Honorary Senior Registrar in the Nuffield Department of Pathology, John Radcliffe Hospital, Oxford. 

As a trainee in Histopathology, I reported surgical biopsies, cytology and undertook post mortems. I also taught clinical medical students.

In 1989, I was awarded a number of grants, including funding from the British Heart Foundation, which allowed me to start my own research group with my own DPhil student (A.L. Ramshaw).

In September 1989, I was awarded a Junior Research Fellowship at Wolfson College, Oxford.

Education

Education
Oct 1984 - Aug 1987

PhD

University of Cambridge

BRITISH HEART FOUNDATION JUNIOR RESEARCH FELLOW, UNIVERSITY OF CAMBRIDGE, DEPARTMENT OF PATHOLOGY.

RESEARCH FELLOW, DARWIN COLLEGE, CAMBRIDGE.

In 1984, I was awarded a three year Junior Research Fellowship from the British Heart Foundation to support my research entitled "Studies on Inflammation in Atherosclerosis".

While doing my research in the University of Cambridge, Department of Pathology, I held an honorary Senior House Officer (SHO) post in the Department of Histopathology & Morbid Anatomy, Addenbrooke's Hospital, Cambridge (2 sessions per week).

I also taught undergraduates in pathology supervisions from Emmanuel, Gonville & Caius and Fitzwilliam Colleges, Cambridge.

In 1985, I won a Research Fellowship from Darwin College, Cambridge which I held until the completion of my PhD in 1987.

In 1986, I won the British Federation of University Women Scholarship Award and the George Herbert Hunt Travelling Scholarship from the University of Oxford to support a three month Visiting Research Fellowship at the Department of Pathology, Massachusett's General Hospital, Harvard Medical School, Boston, U.S.A.

Sep 1980 - Jul 1983

B.M., B.Ch.

University of Oxford

While studying clinical medicine, I was a graduate student of Wolfson College, Oxford. 

In March 1983, I did my clinical medical elective at the MRC Sickle Cell Unit, Kingston, Jamaica, working with the Unit Director, Graham Serjeant to study immune function in children with sickle cell anaemia.

During my clinical medical studies in Oxford, I won a number of prizes and awards, including:

1982: The Alfred A. Richman Research Award from the American College of Chest Physicians.

1982: The British Nutrition Foundation essay prize.

1982: Radcliffe Infirmary Prize in Obstetrics & Gynaecology.

1983: Medical Research Council Travelling Scholarship in Tropical Medicine.

1983: The ICI Bursary from the Royal College of Pathologists.

1983: The Wellcome Trust Travel Grant.

1983: The Radcliffe Prize in Medicine & Surgery, Oxford University.

1983: The George Pickering Prize (proxime accessit) for the final B.M., B.Ch. examination, University of Oxford.

Sep 1977 - Jun 1980

B.A. (Hons)

University of Cambridge

I attended grammar school in Chesterfield, Derbyshire, England from 1969 to 1976.

In November 1976 I sat the entrance exams for Cambridge University (Biology, Chemistry, Physics and General Studies) and won an entrance scholarship to King’s College, Cambridge University. 

At the University of Cambridge, my pre-clinical studies were in Medical Sciences. 

During 1979/80, I was a student on the Part II Pathology course (Immunology & Cellular Pathology) in the University Department of Pathology, Tennis Court Road.

During this year, I had the opportunity to undertake an undergraduate research project entitled, "Studies on Inflammation in Atherosclerosis". This research involved developing the then new technique of immunohistochemistry and applying it to study the cellular composition of atherosclerosis. 

I had become interested in the immunohistochemical methods of studying tissue at the microscopic level after reading the published work of Clive Taylor, David Y Mason and Kevin Gatter in the mid to late 1970's.

This Part II research project then became the basis for my future PhD studies; the role of immunohistochemistry would become an integral part of my future clinical diagnostic work and future research.

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