David Xiao

Objective

Synthetic Chemist, R&D Chemist, Scale-up Chemist

Summary

·Master’s of Science in Organic Chemistry and ten (10) years of hands-on synthetic chemistry experience in R&D laboratories in pharmaceutical companies

·In-depth theoretical and practical knowledge of organic chemistry

·Independent researching literatures, designing and developing synthetic pathways to target compounds

·Independent and efficient developing multi-step and multi-scale synthetic processes of APIs

·Reliable bench work and hands-on laboratory technologies: preparing and performing reactions including highly sensitive organic and organometallic reactions such as air and/or moisture sensitive, low temperature and high pressure reactions; monitoring the processes of reactions using analytical techniques such as TLC, HPLC, NMR, GC and LC-MS; isolating or purifying compounds using recrystallization, column chromatography, preparative HPLC and Biotage Flash Purification Systems

·Extraordinary experience in developing bench scale processes which can be safely and easily scaled up in kilo-labs and pilot plants

·Characterization of compounds using MS, EA, IR, UV, 1HNMR, 13CNMR, 2D NMR, LC-MS, DSC

·Executingliterature research of compounds and reactions using Scienfinder, Reasyx.com, Chemical Abstract and other paper-based data bases

·Strong independenttechnical analysis such as problem-solving and decision-making based on excellent experiment observations, in-depth knowledge and analytical data

·Preparation of technical records,reports, presentations and technical documents using ACD, Chemoffice, Chemdraw, MS Word, Excel and PowerPoint

·Efficient multi-task player with excellent time and project management

·Outstanding ability to work well in a team environment or as a highly responsible individual with reliability and creativity

·Synthesis ofpeptides using SPPS strategy, modification and conjugation of peptides with proteins, FITC and drugs, purify peptides using preparative HPLC

Work History

Work History
Oct 2009 - May 2010

Research Chemist

Alphora Research

·Searched and researched synthetic literatures, designed synthetic routes of API;

·Developed and optimized multi-scale synthetic processes of API to meet customers’ requirement;

·Analysedand characterized organic compounds through TLC, HPLC, NMR and LC-MS;

·Prepared project report and hazard reaction & material sheets;

·Ordered chemicals for R&D group.

2008 - 2009

Organic Synthetic Chemist

Dalton Pharma Services

Selected Achievements:

·Successfully developed and optimized the process of an active pharmaceutical ingredient for a Canadian pharmaceutical company after other companies failed due to the product’s instability and requirement for high purity.

·Optimized and scaled up the process of a custom peptide resulting in a yield increasing greatly over the original process developed by a predecessor.

·Optimized, simplified and implemented a new process of an originally unstable product developed by a predecessor which had a low yield and intricate process.

main responsibilities:

·Synthesized and purified complex medicinal compounds.

·Developed synthetic process of complex chemicals according to customers’ requirement.

·Scaled up processes of medicinal compounds

·Synthesized, purified and characterized complex peptides using preparative HPLC and LC/MS.

·Developed project’s reports and manuscripts based on the original research.

2007 - 2008

Organic Synthetic Chemist

Advanced Syntech, Inc.

After my research, I developed and implemented a synthetic protocol for a kind of peptides that previously caused the loss of contracts related to old processes, resulting in stronger business partnerships with companies.

main responsibilities:

·Synthesized, purified and characterized complex peptides using preparative HPLC and LC/MS.

·Modified peptides and conjugated peptides with protein.

2002 - 2007

Manager of Synthesis Department

Beijing Guolian Chenghui Pharmaceutical Technology CO. LTD

Selected Achievements:

·Created and optimized the process of Lafutidine (API) which had 15 reaction steps and was the first process scaled up in the pilot plant except the originator’s process resulting in a stable, easily-operated and low cost product that was so competitive the company became a dominant manufacturer in the world.

·Optimized and scaled up the process of Oxiracetam’s key intermediate, improved its quality, sharply reduced its cost and pollution.

·Developed and scaled up over 30 processes of active pharmaceutical ingredients (API): Finasteride, Ziprasidone Hydrochloride, Pazufloxacin Mesilate and Levosimend.

main responsibilities:

·Researched, designed, developed and optimized synthetic routes of active pharmaceutical ingredient (API) in R&D laboratories.

·Scaled up the processes of API and their intermediates in pilot plants.

·Prepared and reviewed the products’ process reports, presentation and SOPs.

·Developed management policies such as reward programs, safety policies and handbooks.

·Planned, organized, and supervised API and their intermediates scale-up and manufacture.

·Collaborated with other technical staffs, salesmen and customers to complete projects.

·Developed the raw materials and intermediates’ quality systems for manufacture under GMP requirements.

·Supervised and trained other chemists to develop the synthesis process of API

2000 - 2002

Senior Researcher

Team Academy pharmaceutical Science

main responsibilities:

·Researched, designed, developed and optimized synthetic routes of active pharmaceutical ingredient (API) in R&D laboratories.

·Scaled up the processes of API and their intermediates in pilot plants.

·Prepared products’ process reports, presentation and SOPs.

·Planned, organized, and supervised API and their intermediates scale-up and manufacture.

Education

Education
1996 - Present

Bachelor of Engineer

Nanchang University
1997 - 2000

Master of Science

Dalian University of Technology

Skills

Skills

synthetic chemist

·        Designed, developed and optimized synthetic routes of API according to technological, regulatory and commercial considerations in industrial synthetic chemistry. ·        Performed background and literature research of compounds and reactions.  Accessed database relevant to the organic synthesis: Scienfinder, Chemical Abstract and Pharmaproject. ·        Developed different levels of synthetic processes from bench scale, pilot scale to full manufacture scale under the constraints of raw materials, economics and regulatory issues. ·        Collected, monitored the processes of reactions using the following analytical techniques: TLC, HPLC, NMR, and LC-MS. ·        Operated highly sensitive organic and organometallic reactions such as air and moisture sensitive, low temperature and high pressure reactions. ·        Strong capabilities in organometallic chemistry and catalyst. ·        Synthesized, modified, conjugated, purified and characterized peptides through preparative HPLC and LC/MS. ·        Prepared reports and presentations using Chemoffice, Chemdraw, Word, Excel and Powerpoint. ·        Managed projects, supervised and collaborated with colleagues.