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Cynthia Alexander

Veterinary Pathologist at Centers for Disease Control and Prevention

Work experience

Jun 2014Present

Veterinary Pathologist

Centers for Disease Control and Prevention
Responsible for leading investigative and regulatory pathology operations at , a biopharmaceutical company focused on the discovery, development and commercialization of siRNA therapies. ▫ Establishing and managing in-house pathology lab services ▫ Interpretation of anatomic and clinical pathology data for toxicity studies ▫ GLP-compliant peer reviews ▫ Preparation and presentation of research reports and presentation of toxicity findings ▫ DSM representative on project teams, from discovery to clinical phase
Jan 2013Jun 2014

Veterinary Pathologist

AstraZeneca
▫ Preclinical drug development and the design of investigative and regulatory safety studies ▫ Interpretation of anatomic and clinical pathology data for toxicity studies in large and small animals ▫ non-GLP and GLP-compliant peer reviews ▫ Preparation and presentation of research reports and presentation of toxicity findings ▫ Development and analysis of models of renal injury ▫ Image analysis of mRNA / microRNA and protein expression using semi-quantitative in situ hybridization (ISH) or immunohistochemistry (IHC) based techniques
Nov 2011Jan 2013

Principal Scientist

Roche
▫ Regulatory safety assessments, including non-GLP preclinical drug development ▫ Supported both small and large-molecule (biologics / therapeutic antibodies) drug development ▫ Interpreted anatomic and clinical pathology data for toxicity studies in dogs, rodents and primates ▫ Presented reports and findings to global management and project teams ▫ Core focus areas included Inflammation and Oncology ▫ Projects included PK/PD studies using MRL/lpr and NZB mouse models of lupus nephritis ▫ Biomarker development including microRNA characterization ▫ Semi-quantitative image analysis of biomarkers for lupus and oncology models
Jan 2011Nov 2011

Associate Professor

University of Adelaide
▫ Provided diagnostic anatomic and clinical pathology service to animal studies and natural disease cases ▫ Necropsy lab supervisor ▫ Course coordinator, Veterinary Pathology; lectured in Clinical Pathology, Ophthalmology, Aquaculture ▫ Funded research areas: the role of innate immunity in infectious diseases and carcinogenesis, biomarkers for canine neoplasias, biospectroscopy applications to pathology / toxicology

Education

20032007

University of Guelph
Anatomic Pathology residency and PhD in innate immunopathology ▫ C.L. Davis Student Award in Veterinary Pathology ▫ Canadian Institutes of Health Research (CIHR) Fellowship ▫ 4 additional academic scholarships
19992003

University of PEI
▫ Graduated 1st in class ▫ 13 separate academic scholarships including 1st in program and the Pathology Achievement Award ▫ President of the student chapter of the American Society of Laboratory Animal Practitioners (ASLAP) ▫ Externships at Massachusetts Institute of Technology, MIT (Lab Animal Med) and UC Davis (Primate Med)
19961999

University of Manitoba
Molecular virology studies ▫ National Sciences and Engineering Research Council (NSERC) scholarship ▫ Manitoba Health Research Council studentship ▫ The University of Manitoba Student Union Scholarship for Excellence
19921996

Dalhousie University
Virology / Molecular Biology ▫ Microbiology & Immunology University Medal (1st in class) ▫ Dalhousie University Entrance Scholarship ▫ Governor General’s Medal (entering Dalhousie, 1st in high school)