Cynthia Alexander

  • Guildford, United Kingdom, GB
Cynthia Alexander

Work History

Work History
Jun 2014 - Present

Veterinary Pathologist

Centers for Disease Control and Prevention
Responsible for leading investigative and regulatory pathology operations at , a biopharmaceutical company focused on the discovery, development and commercialization of siRNA therapies. ▫ Establishing and managing in-house pathology lab services ▫ Interpretation of anatomic and clinical pathology data for toxicity studies ▫ GLP-compliant peer reviews ▫ Preparation and presentation of research reports and presentation of toxicity findings ▫ DSM representative on project teams, from discovery to clinical phase
Jan 2013 - Jun 2014

Veterinary Pathologist

AstraZeneca
▫ Preclinical drug development and the design of investigative and regulatory safety studies ▫ Interpretation of anatomic and clinical pathology data for toxicity studies in large and small animals ▫ non-GLP and GLP-compliant peer reviews ▫ Preparation and presentation of research reports and presentation of toxicity findings ▫ Development and analysis of models of renal injury ▫ Image analysis of mRNA / microRNA and protein expression using semi-quantitative in situ hybridization (ISH) or immunohistochemistry (IHC) based techniques
Nov 2011 - Jan 2013

Principal Scientist

Roche
▫ Regulatory safety assessments, including non-GLP preclinical drug development ▫ Supported both small and large-molecule (biologics / therapeutic antibodies) drug development ▫ Interpreted anatomic and clinical pathology data for toxicity studies in dogs, rodents and primates ▫ Presented reports and findings to global management and project teams ▫ Core focus areas included Inflammation and Oncology ▫ Projects included PK/PD studies using MRL/lpr and NZB mouse models of lupus nephritis ▫ Biomarker development including microRNA characterization ▫ Semi-quantitative image analysis of biomarkers for lupus and oncology models
Jan 2011 - Nov 2011

Associate Professor

University of Adelaide
▫ Provided diagnostic anatomic and clinical pathology service to animal studies and natural disease cases ▫ Necropsy lab supervisor ▫ Course coordinator, Veterinary Pathology; lectured in Clinical Pathology, Ophthalmology, Aquaculture ▫ Funded research areas: the role of innate immunity in infectious diseases and carcinogenesis, biomarkers for canine neoplasias, biospectroscopy applications to pathology / toxicology

Education

Education
2003 - 2007

University of Guelph
Anatomic Pathology residency and PhD in innate immunopathology ▫ C.L. Davis Student Award in Veterinary Pathology ▫ Canadian Institutes of Health Research (CIHR) Fellowship ▫ 4 additional academic scholarships
1999 - 2003

University of PEI
▫ Graduated 1st in class ▫ 13 separate academic scholarships including 1st in program and the Pathology Achievement Award ▫ President of the student chapter of the American Society of Laboratory Animal Practitioners (ASLAP) ▫ Externships at Massachusetts Institute of Technology, MIT (Lab Animal Med) and UC Davis (Primate Med)
1996 - 1999

University of Manitoba
Molecular virology studies ▫ National Sciences and Engineering Research Council (NSERC) scholarship ▫ Manitoba Health Research Council studentship ▫ The University of Manitoba Student Union Scholarship for Excellence
1992 - 1996

Dalhousie University
Virology / Molecular Biology ▫ Microbiology & Immunology University Medal (1st in class) ▫ Dalhousie University Entrance Scholarship ▫ Governor General’s Medal (entering Dalhousie, 1st in high school)