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Work History

Nov 2015Present

Associate Scientist

GVK Bio-sciences, Hyderabad 
  • Screening of NCEs for anti-cancer activity using in vivo xenograft models
  • Re-purposing of various NCEs molecules for prevention/treatment of Pulmonary Arterial Hypertension (PAH)
Nov 2014Nov 2015

Post Doctoral Fellow

GVK Biosciences
  • Re-purposing of various drugs for prevention/treatment of Pulmonary Arterial Hypertension (PAH), vascular inflammation and cancer.
  • PK-PD correlation and safety evaluation of new chemical entities
Feb 2009Feb 2014

Junior and Senior Research Fellow

National Institute of Nutrition, (ICMR), Dept of Health Research, Min. of H &FW, Govt of India, Hyderabad
  • Formulation of hypothesis, objectives to assess the proof of concept / mechanism
  • Pharmacological efficacy and safety evaluation of drugs using in vitro and in vivo techniques

Education

Feb 2009Feb 2015

PhD - Pharmacology

Osmania University, Hyderabad

The in vitro and in vivo studies established the proof of mechanism, that the armoury of polyphenols in combination, potentially abrogates CD36 signalling mediated pathogenic foam cell formation and promote their  emigration from the intima resulted in atheroinflammatory lesion regression.

Jun 2006Jul 2008

M. Pharm - Pharmacology

North Maharashtra University, Jalgaon

Pharmacological mechanistic anti-asthmatic and antianaphylactic activities of a homeopathic drug - B. orientalis were established for the first time. The thermoreversible (PF-127) nasal gel of B. orientalis were formulated which showed better anti-asthmatic activity.

Jun 2002Jun 2006

B. Pharm

Pune University, Pune

AWARDS AND ACHIEVEMENT

  • Selected Junior (02/2009 - 02/2011) and Senior Research Fellow (02/2011 -02/2014) Awarded - National Institute of Nutrition, Indian Council of Medical Research, Govt. of India.
  • Young Pharmacologist Govind Achari Prize by Indian Pharmacological Society - 2011
  • First prize - State level Inter-Pharmacy scientific presentation, Pune, Maharashtra,  India - 2005
  • Best outgoing student of the year - College of Pharmacy, Pune, Maharashtra, India - 2005

PUBLICATIONS

  • Nimgulkar C, Ghosh S, Shankar Anand B, Uday Kumar P,  Surekha M V, Madhusudhanachary  P,   Annapurna B R, Dinesh Kumar B.  Combination of spices and herbal extract restores macrophage foam cell migration and abrogates the athero-inflammatory signalling cascade of atherogenesis,  Vascul Pharmacol, 2015; 72: 53-63. [PMID: 25869517]
  • Nimgulkar C, Edula S, Racha V, Chalamaiah M, Shyam P, Ravindranath A,  Dinesh  Kumar  B.,  Role of in silico COX2 molecular docking bioinformatics tool and in vivo carrageenan induced various inflammatory phase in mouse and rat models, in evaluation of anti-inflammatory activity of molecules. Int J Pharma Res & Rev, 2014; 3(4):57-65
  • M. Chalamaiah, R. Hemalatha, T. Jyothirmayi, Prakash V. Diwan, P. Uday kumar, Chetan Nimgulkar,  B. Dinesh kumar.,  Immunomodulatory effects of protein hydrolysates from Rohu (Labeo rohita) egg (roe) in BALB/c mice, Food Res Int, 2014, 62, 1054–1061 [doi:10.1016/j.foodres.2014.05.050]
  • Panpatil VV, Tattari S, Kota N, Nimgulkar CC, Polasa K. In-vitro evaluation on   antioxidant    and anti-microbial activity of spice extracts of ginger, turmeric and garlic. J Pharmacognosy and Phytoch; 2013; 2 (3): 143-148
  • Sunitha K, Bhaskara Chary K, Nimgulkar CC, Dinesh Kumar B, Manohar Rao D.,    Identification, quantification and antioxidant activity of Secondary metabolites in leaf and callus extracts of Coleus forskohlii. Int J Pharma Bio Sci; 2013; 4(3): (B) 1139 – 1149.
  • Nimgulkar CC, Patil SD, Dinesh Kumar B. Anti-asthmatic and anti-anaphylactic activity of Blatta orientalis mother tincture. Homeopathy; 2011; 100: 138-43 [PMID: 21784330]
  • Nimgulkar CC, Joshi AA. Anti-Asthmatic and Anti-Anaphylactic Activity of Helicanthus  elastica Desr. Pharmacologyonline; 2010; 2: 14-31
  • Nimgulkar CC, Patil SD, Chauk DS. Evaluation of Blatta orientalis (Φ) nasal gel   formulation in milk aspiration induced eosinophilia. Pharm Dev Technol; 2009; 14(4): 435–441 [PMID: 19552565]
  • Nimgulkar CC, Patil SD. Role of simulator in surgical blood pressure. AATEX 14, Special Issue; 2008; 14: 221-223

PRESENTATIONS

  • Arteriosclerosis, Thrombosis and Vascular Biology (AHA-ATVB)- 2013 (A501) title  “Poly Herbal Formulation Prevents Foam Cell Formation Possibly Through  Attenuation of CD36 Scavenger Receptor Signalling Cascade”, at FL, USA - (ePoster presentation - 1st - 3rd May 2013)
  •  6th World congress on Alternatives and Animal use in the life sciences, title "Role of simulator in surgical blood pressure" Tokyo,  JAPAN  - (Oral presentation - 21st -25th August 2007)
  • 42nd Nutrition Society of India National meeting, Mumbai Chapter, Mumbai : Nimgulkar CC, Polasa K, Venkaiah K, Dinesh Kumar B. Combination ofNutraceutical (Garlic, Ginger, Turmeric) and Herbal (Terminalia arjuna, Cyprus rotundus) as Potential Anti-oxidant and Anti-inflammatory agents - (Oral Presentation - 09/2010)
  • 29th Annual conference of Society of Toxicology, India at NIN (ICMR), Hyderabad,  ‘Safety efficacy validation of traditional medicinal plant Sarcostemma  acidum’  -(Poster - 2009)
  • 58th Indian Pharmaceutical Congress at Mumbai, ‘Spectrometric determination of Meloxicam from solid and gel dosage forms - (Poster - 2007)
  • APTI at Visakhapatnam: ‘Drug receptor binding’ - (Poster - 2004) 
  • First Indian congress on Alternatives to the use of animals in research, testing and education, Chennai, India - (Demonstration - 29th -31st January 2007)

AFFILIATIONS

  • Life member of Indian Pharmacological Society (IPS)
  • Life member of Nutrition Society of India (NSI)
  • American Heart Association (AHA-ATVB)

REFERENCES

Dr. J. B. Gupta, Chief Scientific Officer
Collaborative Research
GVK Biosciences Private Limited, Hyderabad: 500 076, India
M: +91-0986656310
Email ID: gupta.jb@gvkbio.com

Dr. B. Dinesh Kumar, PhD, FAPASc, FIPS
Scientist ‘F’ (Deputi Director - Sr.) and PCT-Coordinator
Center for Advanced Research for Preclinical Toxicology Center
Food and Drug Toxicology Research Center
National Institute of Nutrition (ICMR), Govt. of India, Hyderabad, 500 007, India.
T: +91 (040) 27197322, M: +91 9849082088
Email: nindineshpct@gmail.com

Dr. B. Sesikeran, MD, FNAMS, FAPASc
Former Director-National Institute of Nutrition, ICMR
Guest Faculty University of Hyderabad
Chairman RCGM
Chairman- Scientific Panel- FSSAI, Hyderabad, 500 007, India.
M: +91-9849081993, R: +91 -40-27173055
Email: sesikeran@gmail.com