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Planning to relocate immediately

Summary

A keen pharmacological seeker with expertise in constructing hypothesis and performing research to develop new proof of concept or mechanism and pharmaceutical products, seeking an opportunity to contribute to the professional growth of the organization.

Strong scientific, technical qualifications and a PhD in Pharmaceutical Sciences-Pharmacology with over years of multinational and diverse experience in the pharmaceutical industry. 

I support project management, investigators and research teams for compliance to study treatment, safety monitoring and efficacy evaluation. I collect, review and analyze study data, prepare and review study report and relevant documents for submission of study reports. I coordinates with internal stakeholders such as business development team, R&D) & external stakeholders for the completion of assigned research project timely and successful.

AWARDS AND ACHIEVEMENT

  • Outstanding Achiever for exceptional performance by GVK Biosciences- 02/2017
  • Selected Junior (02/2009 - 02/2011) and Senior Research Fellow (02/2011 -02/2014) Awarded - National Institute of Nutrition (ICMR), Govt. of India.
  • Young Pharmacologist Govind Achari Prize by Indian Pharmacological Society - 2011
  • First prize - State level Inter-Pharmacy scientific presentation, Pune, Maharashtra, India - 2005
  • Best outgoing student of the year - Sinhgad College of Pharmacy, Pune, Maharashtra, India - 2005

Work experience

Nov 2015Present

Scientific Manager

GVK Bio-sciences, Hyderabad
  • Formulation of research question, hypothesis, aim and objectives to investigate proof of concept / mechanism, research study design, study execution, data analysis and interpretation, study conclusion, PK-PD correlation
    • Cardiovascular Pharmacology: PAH - CaSR, PDE5, ET1 receptor expression
    • Cancer immunotherapy: Antibody targeted PD-1 receptor and EMT pathway
    • Metabolic Diseases: Targeting CD36, PPAR-α/γ, Src kinases-NF-kB mediated inflammatory & oxidative stress to prevent progression of NASH, HCC, Atherosclerosis
    • Pain and Inflammation: neuropathic pain, IPF and psoriasis
Nov 2014Nov 2015

Post Doctoral Fellow

GVK Biosciences
  • Re-purposing of various drugs for prevention/treatment of PAH, NASH and cancer
  • PK-PD correlation and safety evaluation of new chemical entities
Feb 2009Feb 2014

Junior and Senior Research Fellow

National Institute of Nutrition, (ICMR), Govt of India, Hyderabad
  • Formulation of hypothesis, objectives to assess the proof of concept / mechanism
  • Pharmacological efficacy and safety evaluation of NCEs using in vitro and in vivo techniques

Education

Feb 2009Feb 2015

PhD - Pharmacology

Osmania University, Hyderabad

In vitro and in vivo studies established the proof of mechanism, that the armoury of polyphenols, potentially abrogates CD36 signalling mediated pathogenic foam cell formation and promote their emigration from the intima which resulted in atheroinflammatory lesion regression.

Jun 2006Jul 2008

M. Pharm - Pharmacology

North Maharashtra University, Jalgaon

Pharmacological mechanistic anti-asthmatic and antianaphylactic activities of B. orientalis were established for the first time. The thermoreversible (PF-127) nasal gel of B. orientalis were formulated which showed better anti-asthmatic activity.

First Class: 68.5%

Jun 2002Jun 2006

B. Pharm

Pune University, Pune

 First Class: 67.5%

Jan 2007Sep 2007

Professional Diploma in Clinical Research

Catalyst Clinical Services

Clinical trial phases, ICH-GCP Guideline, Protocol preparation, Study design (Randomized controlled trial (blind, non-blind and adaptive clinical trial), case report, case series, cohort study, prospective cohort, retrospective cohort, case-control study, cross-sectional study),  CRF, ADR, AE, data analysis, interpretation, report writting

PUBLICATIONS

  • Nimgulkar C, Ghosh S, Shankar Anand B, Uday Kumar P, Surekha M VM, adhusudhanachary P, Annapurna B R, Dinesh Kumar B. Combination of spices and herbal extract restores macrophage foam cell migration and abrogates the athero-inflammatory signalling cascade of atherogenesis, Vascul Pharmacol, 2015; 72: 53-63. [PMID: 25869517] (IF: 3.63)
  • Nimgulkar C, Edula S, Racha V, Chalamaiah M, Shyam P, Ravindranath A, Dinesh K umar B., Role of in silico COX2 molecular docking bioinformatics tool and in vivo carrageenan induced various inflammatory phase in mouse and rat models, in evaluation of anti-inflammatory activity of molecules. Int J Pharma Res & Rev, 2014; 3(4):57-65
  • Chalamaiah, R. Hemalatha, T. Jyothirmayi, Prakash V. Diwan, P. Uday kumar, Chetan Nimgulkar, B. Dinesh kumar., Immunomodulatory effects of protein hydrolysates from Rohu (Labeo rohita) egg (roe) in BALB/c mice, Food Res Int, 2014, 62, 1054–1061 [doi:10.1016/j.foodres.2014.05.050] (IF: 3.85)
  • Dube N, Nimgulkar C, Dinesh Kumar B, 2017. Validation of therapeutic anti-inflammatory potential of Arjuna Ksheera Paka A traditional Ayurvedic formulation of Terminalia arjuna, J Trad Comp Medi, 7, 414- 420
  • Panpatil VV, Tattari S, Kota N, Nimgulkar CC, Polasa K. In-vitro evaluation on antioxidant a nd anti-microbial activity of spice extracts of ginger, turmeric and garlic. J Pharmacognosy and Phytoch; 2013; 2 (3): 143-148
  • Sunitha K, Bhaskara Chary K, Nimgulkar CC, Dinesh Kumar B, Manohar Rao D., I d entification, quantification and antioxidant activity of Secondary metabolites in leaf and callus extracts of Coleus forskohlii. Int J Pharma Bio Sci; 2013; 4(3): (B) 1139 – 1149.
  • Nimgulkar CC, Patil SD, Dinesh Kumar B. Anti-asthmatic and anti-anaphylactic activity of Blatta orientalis mother tincture. Homeopathy; 2011; 100: 138-43 [PMID: 21784330] (IF: 1.175)
  • Nimgulkar CC, Joshi AA. Anti-Asthmatic and Anti-Anaphylactic Activity of Helicanthus elastica Desr. Pharmacologyonline; 2010; 2: 14-31

PRESENTATIONS

  • Arteriosclerosis, Thrombosis and Vascular Biology (AHA-ATVB)- 2013 (A501) title “Poly Herbal Formulation Prevents Foam Cell Formation Possibly Through Attenuation of CD36 Scavenger Receptor Signalling Cascade”, at FL, USA - (ePoster presentation - 1st - 3rd May 2013)
  • 6th World congress on Alternatives and Animal use in the life sciences, title "Role of simulator in surgical blood pressure" Tokyo,  JAPAN  - (Oral presentation - 21st -25th August 2007)
  • 42nd Nutrition Society of India National meeting, Mumbai Chapter, Mumbai : Nimgulkar CC, Polasa K, Venkaiah K, Dinesh Kumar B. Combination ofNutraceutical (Garlic, Ginger, Turmeric) and Herbal (Terminalia arjuna, Cyprus rotundus) as Potential Anti-oxidant and Anti-inflammatory agents - (Oral Presentation - 09/2010)
  • 29th Annual conference of Society of Toxicology, India at NIN (ICMR), Hyderabad, ‘Safety efficacy validation of traditional medicinal plant Sarcostemma  acidum’  -(Poster - 2009)
  • 58th Indian Pharmaceutical Congress at Mumbai, ‘Spectrometric determination of Meloxicam from solid and gel dosage forms - (Poster - 2007)
  • APTI at Visakhapatnam: ‘Drug receptor binding’ - (Poster - 2004) 
  • First Indian congress on Alternatives to the use of animals in research, testing and education, Chennai, India - (Demonstration - 29th -31st January 2007)

AFFILIATIONS

  • Life member of Indian Pharmacological Society (IPS)
  • Life member of Nutrition Society of India (NSI)
  • American Heart Association (AHA-ATVB)

REFERENCES

  1. Dr. Muthusamy Shanmuganathan, PhD
    2nd Clinical Scientific Expert, 
    Novartis, Hyderabad, India.
    M: +91-7207136808
    Email: [email protected]
  2. Dr. B. Dinesh Kumar, PhD, FAPASc, FIPS
    Scientist ‘F’ (Depute Director - Sr.) and PCT-Coordinator
    Center for Advanced Research for Preclinical Toxicology Center
    Food and Drug Toxicology Research Center
    National Institute of Nutrition (ICMR), Govt. of India, Hyderabad, 500 007, India.
    T: +91 (040) 27197322, M: +91 9849082088
    Email: [email protected]
  3. Dr. J. B. Gupta, PhD, Chief Scientific Officer
    Collaborative Research
    GVK Biosciences Private Limited, Hyderabad: 500 076, India
    M: +91-0986656310
    Email: [email protected]