To do biotech diligence analysis for companies interested in venture or long term investment in new or nascent biotech companies
systems biology, photography, travel, poetry
Self-motivated and detail-oriented professional offering 20 years of strong molecular and cellular biology as well as in bioinformatics background honed through extensive work experience in research in healthcare industry. Recognized for expertly combining information from bioinformatics, molecular, and cellular biology and patent literature to identify strengths and weaknesses in novel research initiatives. Renowned for knowledge extraction from databases, extension of knowledge about novel genes or phenomena by data mining and motif analysis, and data integration from a systems biology point of view using ontology for therapeutic product development. Demonstrate strong analytical problem solving and decision making skills; prompt in responding to all challenges with confidence, determination, and focus.
CORE COMPETENCIESTranslational Research,Functional Genomics,Stem Cell Technology,Microarray Analysis,Gene Expression Profiling ,Biomarker Discovery,Systems Biology ,Cytokine Discovery and Profiling,High Throughput Sequence Analysis ,Subunit Vaccine Development
Director of Bioinformatics and Molecular Biology
Initiated research projects on novel therapeutic molecules by mining public databases, cloning and expression studies.Submitted R01 grants for research.
Apr 2011 - Jul 2012
Staff Scinetist Bioinformatics Core
Conducted systems biology analysis on high throughput gene expression data to identify genes modulated in malaria patients; or by TLR7 in transgenic mice; as well as genes modulated by agonist antibodies in NK cells.
Spearheaded the standardization of protein array normalization and statistical analysis.
Identified immunogenic proteins in Plasmodium falciparum protein array experiments.Carried out the assignment of Plasmodium falciparum proteins expression to different stages by combining MASS spec and transcriptome data.Demonstrated cytokine profile changes by malaria infection by analyzing Luminex data
Mar 2006 - Sep 2011
Consultant Bioinformatics and Molecular Biology
Established specific gene expression patterns in human neural stem cells during differentiation as well as in response to specific neurogenic chemicals.Provided molecular biology expertise for optimal expression of therapeutically relevant foreign genes in transfected neural stem cells in vivo.
Apr 2005 - Apr 2011
Bioinformatics Core Specialist
Coordinated with several principal investigators to determine targets of specific genes in CNS in gene knockout experiments.Identified genes modulated by neuropeptide PACAP in different experimental systemsTook charge of identifying genes which are modulated by TNF in bovine chromaffin cells.Conceptualized and devised methods for functional annotation of novel genes.Maintained the Science Signaling website for connection map for PC12 differentiation. Created a database by integrating microarray studies done at SMN (Section on Molecular Neuroscience).Supervised the creation of a database of gene expression in brain by various antidepressants
Apr 2010 - Apr 2011
H J Foundation for the Advancement of Military Medicine, Inc
Developed neurotrauma database through text mining the effect of different traumatic brain injuries on different brain regions at the transcriptional level.Executed thorough studies regarding the impact of trauma on microRNA and transcriptome through analyzing microarray and deep sequence data.
Mar 2004 - Jul 2005
Staff scientist, oncology
Johns Hopkins University—School of Medicine
Identified the genes modulated during hematopoietic stem cells undergoing differentiation in vitro.
Mar 2003 - Mar 2005
Special volunteer scientist in Bioinformatics
Analyzed microarray data from different gene knockout model systems in relation to their effects on neuronal differentiation and behavior.
Oct 2000 - Jun 2003
Principal Scientist, Gene Discovery
Categorized differentially expressed and stage specific genesets in human neural stem cells and also as a response to specific chemicals (Affymetrix microarrays).Identified more than 12000 novel brain stem cell specific transcript tags by developing a novel 5’ SAGE technology.
Jul 2002 - Jan 2003
Determined genesets by integrating gene expression information from post mortem brain, cell culture, and in animal model systems for high throughput screening of novel therapeutics for depression, Schizophrenia, and bipolar disorder
Aug 1981 - Nov 1999
Research Scientist I, II and III
Developed a signal trap procedure and used it for identifying genes encoding secreted proteins.Cloned, expressed and studied the functions of PBEF (Visfatin), LIF, Proteinase T and TNF and quite a few other novel secreted proteins in both in vitro and in vivo model systems. Cloned and expressed different spliced forms of human thrombopoietin.
Sep 1979 - Aug 1981
Jul 1977 - Aug 1979
Baylor College of Medicine
Jun 1973 - Jul 1977
University of Southern California