Barrett Larson, MD 

Barrett Larson, MD 

Professional Education

Education
2011 - 2015

Internship and Residency (Anesthesiology)

Stanford University School of Medicine
2006 - 2011

Doctor of Medicine

Stanford University School of Medicine
2010 - 2010

Stanford Ignite (Entrepreneurship Program)

Stanford Graduate School of Business
2001 - 2006

B. S. (Honors) in Biology

University of California, San Diego

Appointments

Work History
2015 - Present

Founder and Director

Stanford Anesthesia Innovation Lab (SAIL)

SAIL is an award-winning medical device incubator focused on accelerating the development of anesthesia-related medical devices.  Our work has been honored by funding and awards from the Society for Technology in Anesthesia (STA), Fellowship in Anesthesia Education and Research (FAER), Spectrum MedTech, and the NIH.  I oversee SAIL projects and direct the fellowship program.  

2010 - Present

Co-Founder and Chief Medical Officer

Leaf Healthcare

Leaf Healthcare is a venture-backed company that has developed a revolutionary wireless patient monitoring platform designed to improve healthcare efficiency and quality throughout the continuum-of-care.  I'm responsible for leading the discovery and development of products that are fundamental to Leaf Healthcare's commercial pipeline.  I also oversee all clinical development operations, including pre-clinical activities and clinical trials.   

Jun 2009 - Jul 2010

Medical Research Scholar

Stanford Institute for Regenerative Medicine

My research was focused on elucidating the mechanisms underlying scarless fetal wound healing.  My research resulted in several abstracts, book chapters, peer-reviewed publications and national presentations.   

2009 - 2010

Teaching Assistant

Stanford University School of Medicine 

I organized and taught a course for pre-clinical medical students called "Student Rounds".  Each week, an interesting clinical case was presented and I would lead students through the diagnostic workup and treatment approach.    

Jun 2007 - Aug 2007

Lead Instructor

Stanford Premedical Summer Program

I organized and lead a course for disadvantaged undergraduates interested in pursing a career in medicine.  The course was an intensive summer program designed to prepare students for the Medical College Admission Test (MCAT).  

May 2002 - Jun 2006

Undergraduate Research Fellow

Cancer Pharmacology Lab, University of California

My research was focused on elucidating the mechanisms underlying resistance to cancer chemotherapy.  My research resulted in numerous abstracts, peer-reviewed publications, and presentations.  I received the Doris Howell Undergraduate Research Scholarship in 2003, the Provosts Undergraduate Research Award in 2004, and was the Undergraduate Research Scholar of the Year in 2005.   

Jun 2004 - May 2006

Teaching Assistant

Department of Biology, University of California

Served as a teaching assistant for various courses in biology and biochemistry.  In 2004 and 2005 I was awarded Teaching Assistant of the Year.  

Awards and Honors 

  • Resident Researcher of the Year Award, Stanford Department of Anesthesia (2015)
  • 1st place winner at Western Anesthesia Residents’ Conference (2015)
  • 1st place winner at Society for Technology in Anesthesia conference (2015)
  • Winner of Spectrum MedTech Award, NIH-sponsored (2014)
  • 1st place winner at Western Anesthesia Residents' Conference (2014)
  • Stanford Medical Scholars Research Fellowship Award (2009-2010)
  • Stanford Anesthesia Clinical Research Fellowship Award (2007)
  • Phi Beta Kappa (2005)
  • Doris Howell Undergraduate Research Scholarship (2003-2004)
  • UCSD Research Scholar of the Year Award (2005)
  • Provosts Undergraduate Research Award (2004-2005)
  • UCSD Teaching Assistant of the Year Award (2004-2005)
  • Dean’s Honors List, University of California at San Diego (2001-2006)
  • National Society of Collegiate Scholars (2001)

Abstracts 

  • Ishise H, Kawai K, Larson BJ, Nishimoto S, Nishimoto S, Fujiwara T, Kakibuchi M.  Calcium entry via TRPC3 channels transduce mechanical force and accelerate wound contraction.  The Plastic Surgery Research Council 60th Annual Meeting.  Seattle, Washington (2015) 
  • Ishise H, Kawai K, Larson BJ, Nishimoto S, Nishimoto S, Fujiwara T, Kakibuchi M.  TRPC3 Channels regulate expression of fibronectin via NFkB signaling in response to cyclic strain and contribute to hypertrophic scar formation.  The Plastic Surgery Research Council 60th Annual Meeting.  Seattle, Washington (2015) 

  • Larson BJ. Wearable patient sensor improves pressure ulcer prevention efforts. Medicine X Conference, Stanford University (2014)

  • Larson BJ, Robbins W. Development of an ultraportable fluid cooling device to facilitate the rapid induction of therapeutic hypothermia. Society for Technology in Anesthesia (2014)
  • Larson BJ, Shen DS, Weckwerth M. Novel patient monitoring system enables implementation of dynamic turning protocols in an effort to prevent pressure ulcers. American Society for Anesthesiology (2014)
  • Larson BJ, Shen DS. Development of a disposable wireless sensor for monitoring patient movement and activity. Society for Technology in Anesthesia (2014)
  • Larson BJ, Shen DS. Development of a disposable wireless sensor for monitoring patient movement and activity. Society for Technology in Anesthesia (2014) 
  • Kawai K, Larson BJ, Ishise H, Carré AL, Nishimoto S, Longaker MT, Lorenz HP,  Kakibuchi M.  Serum derived nanoparticles increase the rate of cutaneous wound closure.  22nd annual China-Japan Joint Congress on Plastic Surgery (2013)

  • Ishise H, Kawai K, Larson BJ, Nishimoto S, Kakibuchi M.  Transient receptor potential C3 play an important role in the formation of hypertrophic scar as a mechanical transducer.   Plastic Surgery Research Council 58th Annual Meeting (2013)
  • Kawai K, Larson BJ, Longaker MT, Lorenz HP. Calcium-based nanoparticles accelerate wound healing. 57th Annual Meeting of Plastic Surgery Research Council (2012) 
  • Kawai K,  Larson BJ, Ishise H, Carré AL, Nishimoto S, Longaker MT, Lorenz HP,  Kakibuchi M.  Serum-derived nanoparticles accelerate skin wound healing through a calcium-mediated mechanism.  The 4th Congress of the World Union of Wound Healing Societies (2012)

  • Kawai K, Larson BJ, Carre AL, Longaker MT, Lorenz HP. Serum-derived nanoparticles can cause calcium-mediated cutaneous wound contraction. 56th Annual Meeting of Plastic Surgery Research Council (2011) 
  • Larson BJ, Carre AL, Levi B, James AW, Longaker MT, Lorenz HP. Insights into scar formation via culture of embryonic and postnatal fibroblasts. Plastic Surgery Research Council Special Supplement (2010)
  • Larson BJ, Kawai K, Lorenz HP. The effect of calcium nanoparticles on wound contracture. 2nd Annual Plastic Surgery Research Symposium, Stanford, CA (2010)
  • Safaei R, Larson BJ, Otani S, Cheng T, Gibson MA, Naerdemann W, Howell SB. Transport of cisplatin by the copper efflux transporter ATP7B. American Association for Cancer Research (2005)
  • Safaei R, Larson BJ, Otani S, Cheng T, Gibson MA, Naedermann W, Howell SB. Acquired resistance to cisplatin is accompanied by the increased export of secretory and lysosmal components via exosomes. American Association for Cancer Research (2005) 

Peer Reviewed Publications 

  • Ishise H, Larson BJ, Hirata Y, Fujiwara T, Nishimoto S, Kubo T, Matsuda K, Kanazawa S, Sotsuka Y, Fujita K, Kakibuchi M, Kawai K.  Hypertrophic scar contracture is mediated by the TRPC3 mechanical force transducer via NFkB activation.  Nature Scientific Reports (accepted June 2015)
  • Kawai K, Larson BJ.  The Role of Serum Derived Nanoparticle in the Cutaneous Wound Healing Process.  Acta Med. Hyogo.  2013; 38(1): 77-82

  • Kawai K, Larson BJ (co-first author), Ishise H, Carre AL, Nishimoto S, Longaker MT, Lorenz HP. Calcium-based nanoparticles accelerate skin wound healing. PLoS ONE (November 2011), 6(11): e27106. doi:10.1371/journal.pone.0027106 
  • Carre AL, Larson BJ, Knowles JA, Kawai K, Longaker MT, Lorenz HP. Fetal mouse skin heals scarlessly in a chick chorioallantoic membrane model system.  Annals of Plastic Surgery (2012).   2012 Jul;69(1):85-90.
  • Larson BJ, Longaker MT, Lorenz HP. Scarless Fetal Wound Healing: A Basic Science Review. Plastic and Reconstructive Surgery (October 2010)
  • Safaei R, Otani S, Larson BJ, Rasmussen ML, Howell SB. Transport of Cisplatin by the copper efflux transporter ATP7B. Molecular Pharmacology (February 2008) 
  • Safaei R, Katano K, Larson BJ, Samimi G, Holzer AK, Naerdemann W, Tomioka M, Goodman M, and Howell SB. Intracellular localization and trafficking of fluorescein-labeled cisplatin in human ovarian carcinoma cells. Clinical Cancer Research (January 2005) 
  • Safaei R, Larson BJ, Cheng C, Gibson MA, Otani S, Naerdemann W, and Howell SB. Abnormal lysosomal trafficking and enhanced exosomal export of cisplain in drug-resistant human ovarian carcinoma cells. Molecular Cancer Therapeutics (October 2005)

Book Chapters and Articles

  • Ramsay J, Larson BJ. Circulatory Physiology. Stoelting’s Pharmacology & Physiology in Anesthetic Practice, 5th edition (2015)
  • Larson BJ. More Than a Fashion Statement, Today’s Wearable Technology Can Save Patient Lives. Health Exec Today (2014)
  • Larson BJ, Rohlen BH, Macario A. Medical Device Innovation: An Overview for the Physician-Inventor. Medscape (2011)
  • Larson BJ, Nauta A, Kawai K, Longaker MT, Lorenz HP. Scarring and Scarless Wound Healing in Advanced Wound Repair Therapies. Woodhead Publishing (2010)
  • Nauta A, Larson BJ, Longaker MT, Lorenz HP. Scarless Wound Healing in Principles of Regenerative Medicine, 2nd Edition. Elsevier Publishing (2010). DOI: 10.1016/B978-0-12-381422-7.10006-9

 

Selected Presentations 

  • Larson BJ.  The Medical Device Innovation Process.  Grand Rounds, Department of Anesthesiology, Stanford University School of Medicine (Sept 2015)
  • Larson BJ.  Wearable Technology - Applications in the Hospital Environment.  Wearable Technologies National Conference (July 2015) 
  • Larson BJ. Medical Device Innovation - From Concept to Commercialization. Bio2Device Conference (May 2015)
  • Larson BJ. Development of a device for magnetically-guided non-optical intubation. Western Anesthesia Residents' Conference (May 2015)
  • Larson BJ.  Development of a device for magnetically-guided non-optical intubation.  Society for Technology in Anesthesia Conference (Jan 2015)
  • Larson BJ. Acute intraparenchymal hemorrhage and cerebral herniation immediately following cranioplasty. Western Anesthesia Residents' Conference (May 2015)
  • Larson BJ. Wearable patient sensor improves pressure ulcer prevention efforts. Medicine X Conference (Sep 2014) 
  • Larson BJ. Novel patient monitoring system enables implementation of dynamic turning protocols in an effort to prevent pressure ulcers. American Society of Anesthesiologists National Conference. (Nov 2014)
  • Larson BJ.  An ultraportable fluid-cooling device for the prehospital care environment.  Western Anesthesia Residents' Conference (May 2014)
  • Larson BJ, Shen DZ. An RFID-based wireless patient monitoring device. Society for Technology in Anesthesia National Conference (Dec 2011)
  • Larson BJ, Carre AL, Levi B, James AW, Longaker MT, Lorenz HP. Insights into scar formation via culture of embryonic and postnatal fibroblasts. 55th Annual Plastic Surgery Research Council National Conference, San Francisco, CA (2010)
  • Larson BJ, Kawai K, Lorenz HP. The effect of calcium nanoparticles on wound contracture. 2nd Annual Plastic Surgery Research Symposium, Stanford, CA (2010)
  • Larson BJ, Czechowicz A, Sohan J, Pantalena L. Nutrition Education Available to the Bay Area Food Stamp Community. Stanford University Research Symposium, Stanford, CA (2007)
  • Larson BJ. Membrane Trafficking Anomalies in Cisplatin Resistant Cells. UCSD Faculty Club, San Diego, CA (2005)
  • Larson BJ. Mechanisms of Acquired Resistance to Chemotherapy. Doris Howell Foundation’s Annual Symposium, La Jolla, CA (2004)