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Objective

To utilize my skills and experience in structural biology and team based therapeutic development to aid in the discovery of cures for and treatment of illness and disease.

Publications

Ph.D. Dissertation:

Structural Determination and Refinement of the Gramicidin A Transmembrane Channel as Studied by Solid State Nuclear Magnetic Resonance Spectroscopy
Randal R. Ketchem
FSU call number QP551.K47 1995.
Order a copy at ProQuest.
PDF Version.

Peer Reviewed:

  1. A Central Nervous System-Restricted Isoform of the Interleukin-1 Receptor Accessory Protein Modulates Neuronal Responses to Interleukin-1
    Dirk E. Smith, Brian P. Lipsky, Chris Russell, Randal R. Ketchem, Jacqueline Kirchner, Kelly Hensley, Yangyang Huang, Wilma J. Friedman, Vincent Boissonneault, Marie-Michèle Plante, Serge Rivest and John E. Sims
    Immunity 2009, v20, n6, 817-831

     

  2. Electrophoretic evidence for the presence of structural isoforms specific for the IgG2 isotype
    Amy Guo, Mei Han, Theresa Martinez, Randal R. Ketchem, Shawn Novick, Claudia Jochheim, Alain Balland
    Electrophoresis 2008, 29, 2550-2556

     

  3. A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing
    Brian A. Rabinovich, Randal R. Ketchem, Martin Wolfson, Lynn Goldstein, Marylin Skelly and David Cosman
    Immunology and Cell Biology (2008) 86, 489-496

     

  4. Disulfide Connectivity of Human Immunoglobulin G2 Structural Isoforms
    Theresa Martinez, Amy Guo, Martin J. Allen, Mei Han, Danielle Pace, Jay Jones, Ron Gillespie, Randal R. Ketchem, Yuling Zhang, and Alain Balland
    Biochemistry (2008) 47, 7496-7508

     

  5. Biophysical Characterization of Structural Properties and Folding of Interleukin-1 Receptor Antagonist
    Ramil F. Latypov, Timothy S. Harvey, Dingjiang Liu, Pavel V. Bondarenko, Tadahiko Kohno, Roger A. Fachini II, Robert D. Rosenfeld, Randal R. Ketchem, David N. Brems, and Andrei A. Raibekas
    Journal of Molecular Biology (2007) 368, 1187-1201

     

  6. A Single Amino Acid Difference between Human and Monkey Interleukin (IL)-1B Dictates Effective Binding to Soluble Type II IL-1 Receptor
    Dirk E. Smith, Randal R. Ketchem, Heather Moore, Zachary Anderson, Blair R. Renshaw, Della J. Friend, and John E. Sims
    The Journal of Biological Chemistry, Vol. 277, No. 49, Issue of December 6, pp. 47619-47625, 2002

     

  7. Biophysical Characterization of a Soluble CD40 Ligand (CD154) Coiled-Coil Trimer: Evidence of a Reversible Acid-Denatured Molten Globule
    James E. Matsuura, Arvia E. Morris, Randal R. Ketchem, Emory H. Braswell, Ralph Klinke, Wayne R. Gombotz, and Richard L. Remmele, Jr.
    Archives of Biochemistry and Biophysics, Vol. 392, No. 2, August 15, pp. 208-218, 2001

     

  8. Four New Members Expand the Interleukin-1 Superfamily
    Dirk E. Smith, Blair R. Renshaw, Randal R. Ketchem, Marek Kubin, Kirsten E. Garka, and John E. Sims
    The Journal of Biological Chemistry, Vol. 275, No. 2, Issue of January 14, pp. 1169-1175, 2000

     

  9. Binding-Induced Activation of DNA Alkylation by Duocarmycin SA: Insights from the Structure of an Indole Derivative-DNA Adduct
    Jason R. Schnell, Randal R. Ketchem, Dale L. Boger, and Walter J. Chazin
    Journal of the American Chemical Society 1999, 121, 5645-5652

     

  10. The three-dimensional structure of Ca2+-bound calcyclin: implications for Ca2+-signal transduction by S100 proteins
    Mallika Sastry, Randal R Ketchem, Orlando Crescenzi, Christoph Weber, Michael J Lubienski, Hiroyoshi Hidaka and Walter J Chazin
    Structure 15 February 1998, 6:223-231

     

  11. High-resolution polypeptide structure in a lamellar phase lipid environment from solid state NMR derived orientational constraints
    RR Ketchem, B Roux and TA Cross
    Structure 15 December 1997, 5:1655-1669

     

  12. Macromolecular structural elucidation with solid-state NMR-derived orientational constraints
    R. R. Ketchem, K. -C. Lee, S. Huo, and T. A. Cross
    Journal of Biomolecular NMR, 8 (1996) 1-14

     

  13. Conformational trapping in a membrane environment: A regulatory mechanism for protein activity?
    S. Arumugam, S. Pascal, C. L. North, W. Hu, K-C. Lee, M. Cotten, R. R. Ketchem, F. Xu, M. Brenneman, F. Kovacs, F. Tian, A. Wang, S. Huo, and T. A. Cross
    Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, pp. 5872-5876, June 1996

     

  14. High-Resolution Conformation of Gramicidin A in a Lipid Bilayer by Solid-State NMR
    R. R. Ketchem, W. Hu, T. A. Cross
    Science 261, 1457 (1993)

     

Invited:

  1. Computational Refinement Through Solid State NMR and Energy Constraints of a Membrane Bound Polypeptide.
    R.R. Ketchem, B. Roux and T.A. Cross
    Biological Membranes: A Molecular Perspective from Computation and Experiment

     

  2. Structure and dynamics from solid state NMR spectroscopy
    RR Ketchem, W Hu, F Tian and TA Cross
    Structure, 15 August 1994, 2:699-701

     

  3. High Resolution Polypeptide Structure in Anisotropic Environments: The Gramicidin Channel
    T.A. Cross, R.R. Ketchem, W. Hu, K.C. Lee, N.D. Lazo and S. Huo
    Proceedings of the Conference on Stable Isotope Applications in Biomolecular Structure and Mechanisms, 1994

     

  4. Structure and Dynamics of a Membrane Bound Polypeptide
    T.A. Cross, R.R. Ketchem, W. Hu, K.C. Lee, N.D. Lazo and C.L. North
    Bulletin of Magnetic Resonance 14(1-4): 96-101, 1993

     

Patents Issued:

  1. TRAIL Receptor-2 Polypeptides and antibodies
    Published: August 2, 2007
    Issued: April 21, 2009
    Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon; Foltz, Ian; Feng, Xiao; Fitch, Alison; Foster, Stephen; Ketchem, Randal R.
    United States Patent 7,521,048
    PDF of issued patent.

     

  2. TWEAK receptor
    Published: September 22, 2005
    Issued: February 24, 2009
    Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, William C. III
    United States Patent 7,495,086
    PDF of issued patent.

     

Patents Published:

  1. Antigen Binding Proteins to Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9)
    Application number: 20090142352
    Filing Date: August 22, 2008
    Inventors: Simon Mark Jackson, Nigel Pelham Clinton Walker, Derek Evan Piper, Bei Shan, Wenyan Shen, Joyce Chi Yee Chan, Chadwick Terence King, Randal Robert Ketchem, Christopher Mehlin, Teresa Arazas Carabeo, Qiong Cao

     

  2. Erythropoietin receptor agonists
    Application number: 11/786,879
    Publication number: US 2008/0124340 A1
    Filing Date: April 13, 2007
    Inventors: Luis G. Borges, Randal R. Ketchem, Ai Ching Lim, Christopher Mehlin, Hongxing Zhou

     

  3. IL-1 Family Variants
    Application number: 20080241096
    Filing Date: October 2, 2008
    Inventors: John E. Sims, Blair R. Renshaw, Christopher Gabel, Jennifer E. Towne, Randal R. Ketchem

     

  4. Cytokine polypeptides
    Application number: 11/602,056
    Publication number: US 2007/0081973 A1
    Filing date: Nov 20, 2006
    Inventors: Peter R. Baum, Bruce A. Mosley, Randal R. Ketchem, Scott L. Taylor

     

  5. Human cytokine and alpha-helix-containing polypeptides
    Application number: 11/634,751
    Publication number: US 2007/0072249 A1
    Filing date: Dec 6, 2006
    Inventors: Peter R. Baum, Randal R. Ketchem, Robert F. DuBose, Steven R. Wiley, Keith N. Kerkof

     

  6. Human and murine cytokine polypeptides
    Application number: 11/177,635
    Publication number: US 2006/0110772 A1
    Filing date: Jul 7, 2005
    Inventors: Peter R. Baum, Bruce A. Mosley, Randal R. Ketchem

     

  7. Human and murine cytokine polypeptides
    Application number: 10/263,568
    Publication number: US 2003/0134306 A1
    Filing date: Oct 2, 2002
    Inventors: Peter R. Baum, Bruce A. Mosley, Randal R. Ketchem

     

  8. Cytokine polypeptides
    Application number: 10/142,717
    Publication number: US 2003/0104579 A1
    Filing date: May 8, 2002
    Inventors: Peter R. Baum, Bruce A. Mosley, Randal R. Ketchem, Scott L. Taylor

     

Photography:

  1. Sunrise on Sea Stacks, Reflected, Oceanside, Oregon
    Randal R. Ketchem
    Outdoor Photographer, 2009 Calendar

     

  2. Coal Lake, Washington
    Randal R. Ketchem
    Outdoor Photographer, Favorite Places, March, 2006

     

Education

Florida State University

Tallahassee, FL, United States
Aug 1989 - Dec 1995
Ph.D., Molecular Biophysics

Ph.D. in Molecular Biophysics at the Florida State University and National High Magnetic Field Laboratory working on Solid State Nuclear Magnetic Resonance Spectroscopy and computational methods for the structure determination of the Gramicidin A transmembrane channel. Advisor Timothy A. Cross.

University of West Florida

Pensacola, FL, United States
Aug 1987 - Aug 1989
B.S., Chemistry

While obtaining my B.S. in Chemistry I worked in the research lab of Dr. John Riehm, performing protein purification using gel columns and HPLC, and performing solid phase peptide synthesis.

Employment History

Amgen Inc.

Seattle, WA, United States
Jul 2002 - Present
Principal Scientist 

Immunex was bought by Amgen, but my research direction has remained focussed on computational structural biology. Working in areas of antibody epitope mapping, molecular assesment, and stability engineering. Serving on therapeutic area teams to lead target development.

Immunex Corporation

Seattle, WA, United States
Nov 1997 - Jul 2002
Scientist 

Computational structural biology involving protein structure determination, analysis and design, protein target discovery, and protein engineering.

The Scripps Research Institute

La Jolla, CA, United States
Feb 1996 - Nov 1997
Postdoctoral Fellow 

Postdoctoral research in Molecular Biology at The Scripps Research Institute working on High Resolution Nuclear Magnetic Resonance Spectroscopy and computational methods for the structure determination of calcium loaded calcyclin and small molecule binders to the minor groove of DNA.

Florida State University

Tallahassee, FL, United States
Dec 1995 - Feb 1996
Postdoctoral Fellow 

Continued as a Postdoctoral Fellow under my Ph.D. advisor, Timothy A. Cross.